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Buy Flagyl (Metronidazole) online Product Name: Flagyl

Generics: Metronidazole

Common Brand Names: Flagil; Metrogyl; Metronidazol

Pharmaceutical Category: Antibiotics / Anti-Infectives

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There is an additional general information about this medication active ingredient metronidazole:

Pharmacological action

Flagyl is an anti protozoal agent. It is believed that the mechanism of action is associated with DNA damage-sensitive microorganisms. Active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, and obligate anaerobic bacteria (including Bacteroides spp., Fusobacterium spp.).
Aerobic bacteria are resistant to metronidazole.
In combination with amoxicillin Flagyl is active against Helicobacter pylori. It is believed that amoxicillin inhibits the development of resistance of Helicobacter pylori to metronidazole.

Pharmacokinetics

Flagyl well absorbed after oral administration. The bioavailability is 80%. Metronidazole is distributed in tissues and body fluids. This medication crosses the placental barrier and the BBB. Binding to plasma proteins is 20%. Metronidazole is metabolized in the liver by oxidation and binding to glucuronic acid. T1/2 is 8 hours. This drug is excreted in the urine (60-80%) and feces (6-15%).

Why is Flagyl prescribed?

Trichomonazice vaginitis and urethritis in women, trichomonazice urethritis in men, giardiasis, amoebic dysentery, anaerobic infections caused by metronidazole-sensitive organisms, combination therapy of severe mixed aerobic-anaerobic infections. Preventing anaerobic infection in surgery (particularly abdominal, urinary tract). Chronic alcoholism.
Flagyl in combination with amoxicillin: chronic gastritis in acute phase, gastric ulcer and duodenal ulcer in acute phase, associated with Helicobacter pylori.
For external and topical use: treatment of acne vulgaris and pink, bacterial vaginosis, treatment of long-term healing of wounds and trophic ulcers.

Dosage and administration

Flagyl is administered for oral use for adults and children over 12 years in 7.5 mg / kg every 6 h or 250-750 mg 3-4 times / day. For children up to 12 years the dose is 5-16.7 mg / kg 3 times / day. For IV injections for adults and children over 12 years starting dose is 15 mg / kg, followed by 7.5 mg / kg every 6 hours or depending on the etiology of the disease - by 500-750 mg every 8 hours. The duration of treatment and frequency of tests is determined individually.
Intravaginally - 500 mg 1 time a night.
In combination with amoxicillin (2.25 g / day) daily dose of metronidazole is 1.5 g; multiplicity of admission - 3 times / day. For patients with severe renal impairment (creatinine clearance less than 30 ml / min) and / or liver daily dose of metronidazole is 1 g (amoxicillin - 1.5 g / day), the multiplicity of the reception is 2 times / day. This medication takes for external and local use 2 times / day, doses are determined individually.
The maximum daily dose for adults when taken orally and IV is 4 g.

Flagyl side effects

Digestive system: nausea, vomiting, anorexia, metallic taste in the mouth.
CNS and peripheral nervous system: headache, nervousness, irritability, insomnia, dizziness, ataxia, weakness, confusion, depression, peripheral neuropathy, seizures, hallucinations.
Allergic reactions: skin rash, itching, hives.
Hemopoietic system: leucopenia.
Local reactions: irritation.
Other: arthralgia, burning sensation in the urethra.

Flagyl contraindications

Organic CNS lesions, blood diseases, liver problems, I trimester of pregnancy, hypersensitivity to metronidazole.

Using during pregnancy and breastfeeding

Metronidazole is rapidly crosses the placental barrier. In II and III trimester of pregnancy Flagyl is used only for health reasons.
Metronidazole is excreted in breast milk. If necessary, use during lactation should solve the issue of termination of breastfeeding.

Special instructions

Patients should with careful use of Flagyl in liver diseases.
In combination with amoxicillin this medication is not recommended for patients younger than 18 years. During the treatment period it is necessary the regular control of pattern of peripheral blood.
During the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men patients should refrain from sexual activity, simultaneous treatment of both partners is mandatory.
During the taking of metronidazole there is a more dark staining of urine.
During treatment with metronidazole should avoid alcohol because to violations of the oxidation of alcohol can accumulate acetaldehyde. As a result may develop reactions similar to those characteristic of disulfiram (abdominal cramps, nausea, vomiting, headache, a sudden rush of blood to the face).

Flagyl drug interactions

Simultaneous administration of Flagyl with:
  • antacids that contain aluminum hydroxide, with kolestiraminom slightly decreases absorption of metronidazole from the gastrointestinal tract;
  • metronidazole potentiates the effect of indirect anticoagulants;
  • disulfiram may develop acute psychosis and impaired consciousness;
  • lansoprazole possible glossitis, stomatitis and / or the appearance of dark color language; with lithium carbonate - may increase the concentration of lithium in blood plasma and the development of symptoms of intoxication with prednisone - increased excretion of metronidazole from the body by accelerating its metabolism in the liver under the influence of prednisone. It is possible a decrease the effectiveness of Flagyl.
  • rifampicin increased the clearance of metronidazole from the body, with phenytoin - it is perhaps a slight increase in the concentration of phenytoin in blood plasma, described the case of toxic action;
  • phenobarbital significantly increased excretion of metronidazole from the body, apparently due to acceleration of its metabolism in the liver under the influence of phenobarbital. It is possible a decrease the effectiveness of Flagyl;
  • fluorouracil enhanced the toxic effect but not the effectiveness of fluorouracil;
  • cimetidine may inhibit the metabolism of metronidazole in the liver that can lead to slow its elimination and increase the concentration in blood plasma. It can not be excluded the increase in the concentration of carbamazepine in plasma and increased risk of toxicity with concomitant use of Flagyl. There was described a case of acute dystonia after a single dose of chloroquine in patients treated with metronidazole.

    Flagyl in case of emergency / overdose

    Symptoms: nausea, vomiting, ataxia, in severe cases - peripheral neuropathy and seizures.
    Treatment: symptomatic, there is no specific antidote.

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