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Buy Fluconazole (Diflucan) online Product Name: Fluconazole

Generics: Fluconazole

Common Brand Names: Elazor; Triflucan; Diflucan

Pharmaceutical Category: Women's Health

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There is an additional general information about this medication active ingredient fluconazole:

Pharmacological action

Fluconazole is an antifungal drug from the group of triazole derivatives. Inhibits the synthesis of ergosterol disrupting the permeability of the cell wall. This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.

Pharmacokinetics

Fluconazole is well absorbed after oral administration. Simultaneous ingestion does not affect absorption. The bioavailability is 90%. Fluconazole is widely distributed in tissues and organs of the body. Its concentration in breast milk, joint fluid, saliva, sputum, vaginal secretions and peritoneal fluid are similar to those in blood plasma. The concentration in the cerebrospinal fluid is 50-90% of the level in blood plasma, regardless of the presence of inflammation of the meninges. In the stratum corneum, epidermis, dermis and sweat fluid concentrations reach values exceeding the concentration in blood plasma. T1/2 is 30 h. Fluconazole is excreted by the kidneys, 80% of the administered dose in an unmodified form.

Why is Fluconazole prescribed?

Cryptococcosis (including cryptococcal meningitis), systemic candidiasis, candidiasis of the mucous membranes, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including AIDS patients). Fungal infections of skin, including athlete's foot, body, groin, pityriasis versicolor, onychomycosis. Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.

Dosage and administration

Dosing regimen of Fluconazole is individual. This medication is prescribed for oral and IV administration. Depending on the testimony of the daily dose is 50-400 mg, the multiplicity of application is 1 times / day. If impaired renal function the dose of fluconazole should be reduced.

Fluconazole side effects, adverse reactions

Digestive system: nausea, abdominal pain, diarrhea, flatulence.
CNS: headache, dizziness.
Allergic reactions: skin rash, anaphylactic reactions.

Fluconazole contraindications

Pregnancy, children up to age 1 year, increased sensitivity to fluconazole and triazole compounds.

Using during pregnancy and breastfeeding

Fluconazole is contraindicated during pregnancy and lactation.
If necessary using this medication during lactation it should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.

Special instructions

Fluconazole should be used with caution in patients with severe impaired liver or kidney diseases.
Therapy can be started before the results of seeding and other laboratory tests. However, an anti-infective therapy should be corrected accordingly when the results of these studies will be known.

Fluconazole drug interactions

Simultaneous administration of Fluconazole with:
  • coumarin anticoagulants marked increase in prothrombin time.
  • rifampicin observed shortening of the half-life of fluconazole. Fluconazole increases the half-life of oral hypoglycemic agents - sulfonylureas (chlorpropamide, glibenclamide, glipizide, tolbutamide) in healthy people. Simultaneous use of fluconazole and oral hypoglycemic agents in diabetic patients is allowed, however, the physician should bear in mind the possibility of hypoglycemia.

    Fluconazole in case of emergency / overdose

    Symptoms: nausea, vomiting, diarrhea and seizures in severe cases.
    Treatment: gastric lavage, forced diuresis, hemodialysis (three-hour dialysis reduces the plasma concentrations of approximately 50%), symptomatic therapy.

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