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Product Name: Prometrium

Generics: Progesterone

Common Brand Names: N / A

Pharmaceutical Category: Women's Health

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There is an additional general information about this medication active ingredient progesterone:

Pharmacological action

Prometrium is a progestogen. This medication causes a transition in the endometrium of proliferative phase, called follicular hormone in the secretory phase, and after fertilization promotes its transition to a state necessary for the development of a fertilized egg. Progesterone reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the breast. It has no androgenic activity. This drug has little effect on protein metabolism, promotes fat deposit and accumulation of glucose in the liver and reduces the reabsorption of sodium in renal tubules.
Prometrium has a blocking effect on the secretion of hypothalamic factors LH and FSH release, inhibits the formation of the pituitary gonadotropin-releasing hormone and inhibits ovulation.

Pharmacokinetics

After IM injection Prometrium is absorbed rapidly and almost completely. This medication metabolized in the liver, the majority of metabolites formed conjugates with glucuronic and sulfuric acids. T1/2 from plasma is a few minutes. This medicine is excreted in the urine - 50-60%, in feces - more than 10%. The number of metabolites which are excreted in the urine varies, depending on the phase of the corpus luteum.

Why is Prometrium prescribed?

Capsules Oral - premenstrual syndrome, fibrocystic breast disease, premenopausal, menopause, including premature, postmenopausal women - as the progestogen component of hormone replacement therapy (HRT) in combination with estrogen; Capsules Vaginal - HRT when dormant in the absence of ovarian progesterone (egg donation), support the luteal phase in preparation for in vitro fertilization, support the luteal phase in spontaneous or induced menstrual cycle, prevention of habitual abortion by threatening and progestogen deficiency, endocrine infertility, prevention of uterine fibroids, endometriosis.
Solution in oil: amenorrhea, oligomenorrhea, algomenorrhea (on the basis of hypogenitalism), anovulatory metrorrhagia, infertility, endocrine (including failure of the corpus luteum), the threat of termination of pregnancy, diagnosis of estrogen.
Gel for external use: mammalgia, disease of the breast.
Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, recurrent miscarriage.
Contraception.

Dosage and administration

Orally, intravaginally, IM, locally. The dosing regimen is individual. The dose, frequency and duration of treatment with Prometrium are determined according to the scheme depending on the indications and the clinical situation.

Prometrium side effects, adverse reactions

Cardiovascular system: increased blood pressure.
Metabolic: edema.
Digestive system: liver problems, jaundice, rarely (with prolonged use) - nausea, vomiting.
Endocrine: rare (with prolonged use) - decreased libido, weight gain, pain and tension in the breasts, irregular uterine bleeding.
CNS: rare (with prolonged use) - headache, depression.

Prometrium contraindications

Severe liver or kidney problems, hepatitis, thromboembolic disease, vaginal bleeding of not established genesis, breast carcinoma (except for cases in which progesterone is used in a combination therapy of this disease).

Using during pregnancy and breastfeeding

In cases of extreme necessity Prometrium may be used during pregnancy in the established failure of the corpus luteum hormone.
Progesterone is not used in women planning a pregnancy in the near future.

Special instructions

Prometrium is used with caution in patients with cardiovascular disease, impaired liver or kidney problems, diabetes, asthma, epilepsy, migraine, depression.

Prometrium drug interactions

Prometrium reduces the intensity of the drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropin-releasing hormone of the anterior pituitary.
This medication reduces the lactogenic effect of oxytocin.
Progesterone enhances the action of diuretics, antihypertensive drugs, immunosuppressive drugs. Simultaneous administration of Prometrium with barbiturates it is marked decrease of progesterone effects.

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