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Chloroquine (Aralen) Product Name: Chloroquine
Generic Name: Chloroquine
Common Brands: Aralen, Lariago, Malarex
Pharmaceutical Categories: Antibiotics, Anti-Infectives

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  • Chloroquine (trade names include Aralen, Cloroquina, Novo-Chloroquine, Avloclor, Delagil, Lariago, Malarex, Resochin, Nivaquine) is an antimalarial medication from aminoquinolines pharmacological group. This medicine is used to treat and prevent malaria infections from Plasmodium vivax, Plasmodium ovale, Plasmodium malariae strains. It is also used for the treatment of amebiasis, amoebic liver abscess, some autoimmune disorders, rheumatoid arthritis, lupus erythematosus, sarcoidosis, in veterinary medicine. Aralen works by damaging DNA of malaria and amoebae. Chloroquine is in clinical, research, biomedicinal science trials as an investigational antiretroviral in humans with HIV-1/AIDS, as a potential antiviral agent against chikungunya fever, in anticancer therapy because of radiosensitizing and chemosensitizing properties, to inhibit lysosomal degradation of protein products.


    Related medications:

  • Acticin (Permethrin)
  • Albenza (Albendazole)
  • Camoquin (Amodiaquine)
  • Cipro (Ciprofloxacin)
  • Lariam (Mefloquine)
  • Malirid (Primaquine)
  • Nizoral (Ketoconazole)
  • Plaquenil (Hydroxychloroquine)
  • Stromectol (Ivermectin)
  • Vermox (Mebendazole)
  • Vibramycin (Doxycycline)


    Pharmacological and medical categories:

  • Amebicides
  • Antiamoebics
  • Antimalarial medications
  • Antimalarial quinolines
  • Disease-modifying anti-rheumatic drugs (DMARDs)
  • Eye anti-infectives and antiseptics
  • Veterinary, pet meds


    ATC codes:

  • P - Antiparasitic products, insecticides and repellents
  • P01 - Antiprotozoals
  • P01B - Antimalarials
  • P01BA - Aminoquinolines
  • P01BA01 - Chloroquine


    ICD-10 codes:

  • Amoebiasis - A06
  • Other mosquito-borne viral fevers - A92
  • Chikungunya virus disease - A92.0
  • Human immunodeficiency virus [HIV] disease - B20
  • Plasmodium falciparum malaria - B50
  • Plasmodium vivax malaria - B51
  • Plasmodium malariae malaria - B52
  • Other parasitologically confirmed malaria - B53
  • Unspecified malaria - B54
  • Neoplasms - C00-D49
  • Sarcoidosis - D86
  • Disorders of glycoprotein metabolism - E77
  • Lupus erythematosus - L93
  • Other rheumatoid arthritis - M06


    Pregnancy categories:

  • Not Classified - Australia
  • Not Classified - United States


    Salts and other forms:

  • Chloroquine Base
  • Chloroquine Diphosphate
  • Chloroquine Hydrochloride
  • Chloroquine Phosphate
  • Chloroquine Phosphate Dibasic
  • Chloroquine Sulphate


    Derivatives used as APIs:

  • Hydroxychloroquine


    Synonyms, international and chemical names:

  • 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline
  • Chloraquine
  • Chlorochin
  • Chlorochina
  • Chlorochine
  • Chlorochinum
  • Chloroquin
  • Chloroquina
  • Chloroquini Phosphas
  • Chloroquini Sulfas
  • Chloroquinium
  • Chloroquinphosphat
  • Chloroquinsulfat
  • Chloroquinum
  • Chlorquin
  • Clorochina
  • Clorocwin
  • Cloroquina
  • Hlorokvin
  • Klorokiini
  • Klorokin
  • Klorokviin
  • Klowokin
  • Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-


    Brands, generics, trade names in various countries:

  • Aralen - Sanofi-Aventis; C.T.S. Chemical Industries
  • Avloclor - AstraZeneca; Teva
  • Chloromax - Oboi Laboratories; Phil Pharmawealth
  • Chloroquine - Sanofi-Aventis; Teva; Watson Pharmaceuticals
  • Clo-Kit - Indoco Remedies
  • Cloroquina - Chile Laboratorios
  • Delagil - ICN Pharmaceuticals
  • Emquin - Merck
  • Klorokin - Zerboni Laboratorios
  • Lariago - Ipca Laboratories; Intima
  • Lariago-DS - Ipca Laboratories
  • Malarex - Alpharma; Actavis; Dumex; KWH Marketing
  • Malaquin - P.C. India Pharma
  • Nivaquine - Sanofi-Aventis; Beacon Pharmaceuticals
  • Nivaquine-P - Sanofi-Aventis; Nicholas Piramal
  • Novo-Chloroquine - Novopharm
  • Plasmoquine - Medchem Pharmaceuticals
  • Resochin - Bayer; Kern Pharma
  • Resochina - Bayer
  • Teva-Chloroquine - Teva


    Pharmaceutical active ingredients used in medicine in combinations with chloroquine:

  • Acetaminophen (Paracetamol)
  • Aminobenzoic Acid
  • Benzyl Alcohol
  • Bulaquine
  • Ephedrine Hydrochloride
  • Fluprednidene Acetate
  • Neomycin Sulfate
  • Prednisolone
  • Primaquine Phosphate
  • Proguanil Hydrochloride
  • Pyrimethamine
  • Quinacrine Hydrochloride
  • Theophylline
  • Vitamin B1 (Thiamine Hydrochloride)
  • Vitamin B5 (Calcium Pantothenate)
  • Vitamin B6 (Pyridoxine Hydrochloride)
  • Vitamin C (Ascorbic Acid)


    References:

  • Chloroquine main article on Wikipedia: https://en.wikipedia.org/wiki/Chloroquine
  • Chloroquine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/chloroquine
  • Chloroquine Hydrochloride compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Chloroquine-hydrochloride
  • Chloroquine Phosphate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Chloroquine-phosphate
  • Chloroquine Sulfate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Chloroquine-sulfate
  • Chloroquine on DrugBank: https://www.drugbank.ca/drugs/DB00608
  • Chloroquine Hydrochloride on DrugBank: https://www.drugbank.ca/salts/DBSALT001317
  • Chloroquine Phosphate on DrugBank: https://www.drugbank.ca/salts/DBSALT000025
  • Chloroquine Sulfate on DrugBank: https://www.drugbank.ca/salts/DBSALT002244
  • Chloroquine FAQ on MedlinePlus: https://medlineplus.gov/druginfo/meds/a682318.html
  • Chloroquine Phosphate tablets film-coated drug label info on DailyMed: https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Chloroquine international drug names on Drugs.com: https://www.drugs.com/international/chloroquine.html
  • Aralen (Chloroquine Phosphate) tablets official prescribing information from the U.S. FDA: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/006002s044lbl.pdf
  • Chloroquine Phosphate tablets 250 mg and 500 mg official prescribing information from the U.S. FDA: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/083082s050lbl.pdf
  • Aralen (Chloroquine Phosphate) tablets prescribing information from Sanofi-Aventis website: http://products.sanofi.us/aralen/Aralen.pdf
  • Aralen (Chloroquine Phosphate) medication guide from MedicineNet: https://www.medicinenet.com/chloroquine-oral/article.htm
  • Avloclor (Chloroquine Phosphate) tablets patient information leaflet on Medicines.org.uk: https://www.medicines.org.uk/emc/files/pil.5490.pdf

    Updated: December 2019
    Reviewed: December 2019



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