Product Name: Vermox
Common Brand Names: D-Worm; Fugacar; Mebex
Pharmaceutical Category: Antibiotics / Anti-Infectives
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There is an additional general information about this medication active ingredient mebendazole:
Vermox is a worming medication a broad spectrum of action, it is most effective when enterobioze. This drug causes irreversible disturbance of glucose utilization in the body of the worm and inhibits the synthesis of ATP.
Vermox is practically not absorbed from the gastrointestinal tract. The plasma protein binding is 90%. This medication is distributed unevenly in organs and accumulates in adipose tissue, liver, and larvae of helminths. Mebendazole is metabolized in the liver to 2-amino derivative.
T1/2 is 2.5-5.5 hours. More than 90% of the dose is excreted unchanged in feces. Grown deep portion (5-10%) is excreted by kidneys.
Why is Vermox prescribed?
Enterobiasis, ascariasis, hookworm disease, strongyloidiasis, trichuriasis, trichinosis, teniasis, echinococcosis, mixed helminth infections.
Dosage and administration
For adults and children over 10 years at enterobioze a single dose is 100 mg.
For children aged 2 to 10 years a single dose is 25-50 mg. In the case of a high probability of re-infestation the drug taking repeats after 2-4 weeks in the same dose.
It is recommended that simultaneous treatment of all family members.
When ascariasis, trichuriasis, hookworm disease, teniasis, strongyloidiasis and mixed helminthiasis - 100 mg in the morning and evening for 3 days. When trichinosis - 200-400 mg 3 times / day for 3 days, from 4th to 10th day - 400-500 mg 3 times / day. When echinococcosis - 500 mg 2 times / day in the first 3 days, then the same dose 3 times / day in the next 3 days. Later mebendazole used in doses of 25-30 mg / kg / day in 3-4 doses.
Vermox side effects, adverse reactions
Digestive system: rarely - nausea, abdominal pain; when used in high doses for long periods of time may be vomiting, diarrhea, transient elevation of liver enzymes in serum.
CNS: Rarely - dizziness when used in high doses for long periods of time - a headache.
Hematopoietic system: when used in high doses for long periods of time may be leukopenia, anemia, eosinophilia.
Urinary system: when used in high doses for long periods of time - hematuria, cylindruria.
Other: when used in high doses for long periods of time - an allergic reaction, hair loss.
Pronounced liver disfunctions, pregnancy, lactation (breastfeeding), children under 2 years of age, hypersensitivity to mebendazole.
Using during pregnancy and breastfeeding
Vermox is contraindicated during pregnancy and lactation (breastfeeding).
Category of the fetus by FDA - C.
With prolonged use of Vermox it is necessary to control the peripheral blood picture, liver and kidney function.
Within days after taking mebendazole avoid drinking alcohol.
After receiving mebendazole do not use a laxative.
It is mandatory a periodic examination of smears of the anal region and the feces after treatment (therapy is effective in the absence of helminths or their eggs for 7 consecutive days).
Vermox drug interactions
Mebendazole reduces insulin requirements in diabetic patients.
It is necessary to avoid a simultaneously taking of Vermox with lipophilic substances. With simultaneous use with cimetidine it may increase, and carbamazepine, and other inducers of metabolism to reduce the concentration of mebendazole in the blood.
Vermox in case of emergency / overdose
Symptoms: nausea, vomiting, diarrhea, abdominal pain. With prolonged use at high doses: reversible hepatic dysfunction, hepatitis, neutropenia.
Treatment: gastric lavage, enemas, activated charcoal method; there is no specific antidote.