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Product Name: Cyclophosphamide
Generic Name: Cyclophosphamide
Common Brands: Cytoxan, Endoxan
Pharmaceutical Categories: Cancer
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Cyclophosphamide (trade names include Cytoxan, Cyclovid, Cycloxan, Cyphos, Endoxan, Genuxal, Neophos, Procytox, Sendoxan) is an antineoplastic and immunomodulating medication from nitrogen mustard analogues pharmacological group. This medicine is used for the treatment of breast cancer, brain cancer, lymphoma, leukemia, sarcoma, osteosarcoma, neuroblastoma, multiple myeloma, bladder cancer, ovarian cancer, testicular cancer, cervical cancer, endometrial cancer, prostate cancer, small and non-small cell lung cancer, Hodgkin's and non-Hodgkin's lymphoma, Wilms' tumor, some solid tumors, mycosis fungoides, autoimmune diseases, systemic lupus erythematosus with severe lupus nephritis, pemphigoid, bullous pemphigoid, pemphigus, minimal change disease, severe rheumatoid arthritis, Goodpasture syndrome, Cogan's syndrome, multiple sclerosis, systemic sclerosis, scleroderma, dermatomyositis, histiocytosis, IgA nephropathy, nephrotic syndrome, AL amyloidosis, granulomatosis with polyangiitis, Graft-versus-host disease (GVHD), for prophylaxis of rejection during and after organ transplantation, in veterinary medicine, and for other medical conditions. It mainly works as a metabolite phosphoramide mustard.
Customers also buy these medications from the same pharmacological classes:
Azathioprine (Imuran)
Bendamustine (Treanda)
Chlorambucil (Leukeran)
Chlormethine (Mustargen)
Colchicine (Colcrys)
Dapsone (Aczone)
Dexamethasone (Decadron)
Hydroxychloroquine (Plaquenil)
Ifosfamide (Ifex)
Melphalan (Alkeran)
Melphalan Flufenamide (Pepaxto)
Methotrexate (Rheumatrex)
Methylprednisolone (Medrol)
Mycophenolic Acid (Cellcept)
Prednimustine (Mostarina)
Prednisone (Deltasone)
Sulfasalazine (Azulfidine)
Trofosfamide (Ixoten)
Pharmaceutical and medical classifications:
Anticancer drugs
Chemotherapy medications
Cytostatic alkylating agents
Disease-modifying antirheumatic drugs (DMARD)
Immunosuppressants
Oncology medicines
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
L - Antineoplastic and immunomodulating agents
L01 - Antineoplastic agents
L01A - Alkylating agents
L01AA - Nitrogen mustard analogues
L01AA01 - Cyclophosphamide
Medical conditions for cyclophosphamide in the International Statistical Classification of Diseases and Related Health Problems:
Malignant neoplasm of bronchus and lung - C34
Malignant neoplasm of bone and articular cartilage of other and unspecified sites - C41
Malignant neoplasm of other connective and soft tissue - C49
Malignant neoplasm of breast - C50
Malignant neoplasm of cervix uteri - C53
Malignant neoplasm of corpus uteri - C54
Malignant neoplasm of endometrium - C54.1
Malignant neoplasm of ovary - C56
Malignant neoplasm of prostate - C61
Malignant neoplasm of testis - C62
Malignant neoplasm of kidney, except renal pelvis - C64
Malignant neoplasm of bladder - C67
Malignant neoplasm of brain - C71
Malignant neoplasm of adrenal gland - C74
Malignant neoplasm of unspecified part of unspecified adrenal gland - C74.90
Malignant neoplasm without specification of site - C80
Hodgkin lymphoma - C81
Follicular lymphoma - C82
Non-follicular lymphoma - C83
Mature T/NK-cell lymphomas - C84
Mycosis fungoides - C84.0
Other specified and unspecified types of non-Hodgkin lymphoma - C85
Other specified types of T/NK-cell lymphoma - C86
Malignant immunoproliferative diseases and certain other B-cell lymphomas - C88
Multiple myeloma and malignant plasma cell neoplasms - C90
Lymphoid leukemia - C91
Myeloid leukemia - C92
Monocytic leukemia - C93
Other leukemias of specified cell type - C94
Leukemia of unspecified cell type - C95
Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue - C96
Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue - D76
Other disorders involving the immune mechanism, not elsewhere classified - D89
Graft-versus-host disease - D89.81
Amyloidosis - E85
Light chain (AL) amyloidosis - E85.81
Multiple sclerosis - G35
Keratitis - H16
Diffuse interstitial keratitis - H16.32
Pemphigus - L10
Pemphigoid - L12
Bullous pemphigoid - L12.0
Granulomatous disorders of skin and subcutaneous tissue - L92
Rheumatoid arthritis with rheumatoid factor - M05
Other rheumatoid arthritis - M06
Other necrotizing vasculopathies - M31
Hypersensitivity angiitis - M31.0
Microscopic polyangiitis - M31.7
Systemic lupus erythematosus (SLE) - M32
Glomerular disease in systemic lupus erythematosus - M32.14
Dermatopolymyositis - M33
Systemic sclerosis [scleroderma] - M34
Recurrent and persistent hematuria - N02
Recurrent and persistent hematuria with diffuse mesangial proliferative glomerulonephritis - N02.3
Nephrotic syndrome - N04
Unspecified nephritic syndrome - N05
Unspecified nephritic syndrome with minor glomerular abnormality - N05.0
Transplanted organ and tissue status - Z94
Pregnancy category:
D - Australia
D - United States (Positive evidence of risk)
Forms of active pharmaceutical ingredients (APIs):
Cyclophosphamide Base
Cyclophosphamide Monohydrate
Cyclophosphamide Hydrate
Chemical, international, and other names of this drug:
Ciclofosfamida
Ciclofosfamide
Cioglafosfaimid
CP
Cycloffosffamid
Cyclofosfamide
Cyclophosphamid
Cyclophosphamidum
Cyklofosfamid
Cytophosphane
Siklofosfamid
Syklofosfamid
Syklofosfamidi
Most known trade names (brands and generics) worldwide:
Adcyclo - Adley Formulations
Cicloxal - Almirall
Cycloblastin - Pfizer
Cyclocel - Celon Labs
Cyclonex - Amdipharm
Cyclophosphamide - Baxter
Cyclovid - Novell Pharmaceutical Laboratories
Cycloxan - Aspar Pharmaceuticals, Biochem Pharmaceutical Industries, Zydus Oncosciences
Cyphos - Intas Pharmaceuticals
Cytophosphane - Taro Pharmaceutical Industries
Cytoxan - Bristol-Myers Squibb, Baxter, Roxane Laboratories
Endoxan - Baxter, Almirall, Asta Medica, Cadila Pharmaceuticals, DKSH, Firma Chun Cheong, German Remedies, Pliva, Sandoz, Sanofi, Shionogi, Teva, Transfarma Medica Indah, Transmedic, Viatris, Zuellig Pharma, Zydus Oncosciences
Endoxana - Baxter, Viatris, Zuellig Pharma
Endoxan-Asta - Baxter, German Remedies, Zydus Cadila
Endoxan-N - Baxter, Cadila Pharmaceuticals
Genoxal - Baxter, Almirall, Kampel Martian Laboratorios
Genuxal - Asta Medica
Neophos - Cipla
Procytox - Baxter, Carter Horner
Sendoxan - Baxter
References and external sources:
Cyclophosphamide main article on Wikipedia: https://en.wikipedia.org/wiki/Cyclophosphamide
Cyclophosphamide compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Cyclophosphamide
Cyclophosphamide Monohydrate on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Cyclophosphamide-monohydrate
Cyclophosphamide medicine on DrugBank: https://go.drugbank.com/drugs/DB00531
Cyclophosphamide Monohydrate on DrugBank: https://go.drugbank.com/salts/DBSALT001814
Cyclophosphamide FAQ on MedlinePlus (revised 08/15/2018): https://medlineplus.gov/druginfo/meds/a682080.html
Cyclophosphamide Injection FAQ on MedlinePlus (revised 08/15/2021): https://medlineplus.gov/druginfo/meds/a611044.html
Cyclophosphamide information on the U.S. National Cancer Institute (revised July 8, 2021): https://www.cancer.gov/about-cancer/treatment/drugs/cyclophosphamide
Baxter Cyclophosphamide tablets drug label on DailyMed (revised August 7, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Ingenus Cyclophosphamide injection solution drug label on DailyMed (revised July 1, 2022): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Baxter Cyclophosphamide tablets for oral use and injection for intravenous use official prescribing information from the U.S. FDA (revised 05/2013): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Ingenus Cyclophosphamide injection for intravenous use official prescribing information from the U.S. FDA (revised 07/2020): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Cyclophosphamide tablets prescribing information from Baxter pharmaceutical company (revised 08/2020): https://www.baxterpi.com/pi-pdf/Cyclophosphamide...
Cyclonex (Cyclophosphamide) 50 mg film-coated tablets product information from The Therapeutic Goods Administration (revised 16 March 2022): https://www.ebs.tga.gov.au/ebs/picmi/...
Endoxan (Cyclophosphamide Monohydrate) powder for injection product information from The Therapeutic Goods Administration (revised 15 January 2021): https://www.ebs.tga.gov.au/ebs/picmi/...
Endoxan (Cyclophosphamide) powder for injection 500 mg, 1 g, 2 g consumer medicine information from NPS MedicineWise (revised 6 May 2003): https://www.nps.org.au/assets/medicines/...
Endoxan (Cyclophosphamide Monohydrate) tablets and injections prescribing information from MIMS: https://www.mims.com/hongkong/drug/info/endoxan?type=full
Baxter Cyclophosphamide tablets 50 mg package information leaflet on Medicines.org.uk (revised 09 December 2016): https://www.medicines.org.uk/emc/medicine/30161
Revised: September 2022
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