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Product Name: Methotrexate
Generic Name: Methotrexate
Common Brands: Imutrex, Rheumatrex, Trexall
Pharmaceutical Categories: Cancer, Arthritis, Rheumatic, Pain Relief
Where to buy Methotrexate online:
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Methotrexate (trade names include Rheumatrex, Abitrexate, Biotrexate, Dermotrex, Ebetrexat, Emthexate, Folitrax, Imutrex, Lantarel, Ledertrexate, Leetrexate, Methoblastin, Methocel, Methotrexat Ebewe, Metoject, Mexate, MTX, Novatrex, Oncotrex, Trexall, Unitrexate) is an antineoplastic and immunomodulating medication from antimetabolites pharmacological group. This medicine is used for the treatment of cancer and neoplastic diseases (such as breast cancer, head and neck, bladder, lung, cervical, ovarian, colorectal, gastric, pancreatic cancer, brain tumor, other solid tumors, gestational trophoblastic disease, leukemia, meningeal leukemia, lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, mantle cell lymphoma, mycosis fungoides, osteosarcoma, soft tissue sarcoma, choriocarcinoma, esophageal carcinoma, trophoblastic neoplasms), autoimmune diseases, rheumatoid arthritis, psoriasis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, systemic sclerosis, myositis, sarcoidosis, lupus, Crohn's disease, Cogan's syndrome, Graft-versus-host disease, eczema, vasculitis, juvenile dermatomyositis, juvenile idiopathic arthritis, uveitis and localised scleroderma in children, ectopic pregnancy, pemphigoid, bullous pemphigoid, pemphigus, pityriasis rubra pilaris. It works as an antimetabolite of the antifolate type.
Related medications:
Adapalene (Differin)
Anastrozole (Arimidex)
Azathioprine (Imuran)
Bicalutamide (Casodex)
Capecitabine (Xeloda)
Celecoxib (Celebrex)
Chlorambucil (Leukeran)
Colchicine (Colcrys)
Cyclophosphamide (Cytoxan)
Darvadstrocel (Alofisel)
Dimethyl Fumarate (Tecfidera)
Diroximel Fumarate (Vumerity)
Eflornithine (Vaniqa)
Erlotinib (Tarceva)
Exemestane (Aromasin)
Fluorouracil (Efudex)
Leflunomide (Arava)
Lenalidomide (Revlimid)
Letrozole (Femara)
Meloxicam (Mobic)
Melphalan (Alkeran)
Pemetrexed (Alimta)
Pimecrolimus (Elidel)
Pirfenidone (Pirfenex)
Pomalidomide (Pomalyst)
Pralatrexate (Folotyn)
Raltitrexed (Tomudex)
Sorafenib (Nexavar)
Tamoxifen (Nolvadex)
Tazarotene (Tazorac)
Thalidomide (Thalomid)
Pharmaceutical and medical classifications:
Abortifacients
Anticancer drugs
Antifolates
Antineoplastic agents
Antipsoriatics
Antirejection medicines
Antirheumatics
Chemotherapy agents
Dihydrofolate reductase inhibitors
Disease-modifying antirheumatic drugs
Immune-system suppressants
Immunosuppressive drugs
Oncology medications
Skin care medicines
Women's health products
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
L - Antineoplastic and immunomodulating agents
L01 - Antineoplastic agents
L01B - Antimetabolites
L01BA - Folic acid analogues
L01BA01 - Methotrexate
L04 - Immunosuppressants
L04A - Immunosuppressants
L04AX - Other immunosuppressants
L04AX03 - Methotrexate
Medical conditions for methotrexate in the International Statistical Classification of Diseases and Related Health Problems (ICD):
Malignant neoplasm of esophagus - C15
Malignant neoplasm of stomach - C16
Malignant neoplasm of colon - C18
Malignant neoplasm of pancreas - C25
Malignant neoplasm of bronchus and lung - C34
Malignant neoplasm of bone and articular cartilage of other and unspecified sites - C41
Malignant neoplasm of other connective and soft tissue - C49
Malignant neoplasm of breast - C50
Malignant neoplasm of cervix uteri - C53
Malignant neoplasm of ovary - C56
Malignant neoplasm of placenta - C58
Malignant neoplasm of bladder - C67
Malignant neoplasm of brain - C71
Malignant neoplasm of other and ill-defined sites - C76
Malignant neoplasm of head, face and neck - C76.0
Malignant neoplasms of lymphoid, hematopoietic and related tissue - C81-C96
Hodgkin lymphoma - C81
Non-follicular lymphoma - C83
Mature T/NK-cell lymphomas - C84
Other specified and unspecified types of non-Hodgkin lymphoma - C85
Leukemia of unspecified cell type - C95
Sarcoidosis - D86
Other disorders involving the immune mechanism, not elsewhere classified - D89
Graft-versus-host disease - D89.81
Keratitis - H16
Iridocyclitis - H20
Crohn's disease [regional enteritis] - K50
Pemphigus - L10
Pemphigoid - L12
Bullous pemphigoid - L12.0
Dermatitis and eczema - L20-L30
Psoriasis - L40
Other papulosquamous disorders - L44
Pityriasis rubra pilaris - L44.0
Other disorders of the skin and subcutaneous tissue - L80-L99
Postinfective and reactive arthropathies - M02
Inflammatory polyarthropathies - M05-M14
Rheumatoid arthritis with rheumatoid factor - M05
Other rheumatoid arthritis - M06
Enteropathic arthropathies - M07
Juvenile arthritis - M08
Systemic lupus erythematosus (SLE) - M32
Dermatopolymyositis - M33
Juvenile dermatomyositis - M33.0
Systemic sclerosis [scleroderma] - M34
Myositis - M60
Ectopic pregnancy - O00
Hydatidiform mole - O01
Pregnancy category:
D - Australia
X - United States (Should not be used during pregnancy)
Forms of active pharmaceutical ingredients (APIs):
Methotrexate Base
Methotrexate Disodium
Methotrexate Sodium
Chemical, international, and other names of this drug:
Amethopterin
Amethopterine
Ametopteriini
Ametopterin
Ametopterina
Ametopteryna
Methotrecsad
Methotrexaat
Methotrexat
Methotrexate
Methotrexatum
Methylaminopterin
Metotreksaatti
Metotreksat
Metotressato
Metotrexat
Metotrexato
MTX
Most known trade names (brands and generics) worldwide:
Abitrexate - Sanofi, Abic, Dynamed Pharmaceuticals, Pharmachemie, R.X. Company, Sanova Pharma, Teva
Artrait - TRB Pharma
Biotrexate - Biochem Pharmaceutical Industries
Dermotrex - East West Pharma
Ebetrexat - Ebewe Pharma, Pharmaforte
Emthexate - Nycomed, Almirall, Asta Medica, Combiphar, Dynamed Pharmaceuticals, F.P. Marketing, Iasis Chemipharma, New Zealand Medical & Scientific, Oriola, Pacific Healthcare, Pharmachemie, R.X. Company, Teva, Union Medical, United Italian Trading
Folitrax - Ipca Laboratories
Imutrex - Cipla
Lantarel - Wyeth
Lantarel FS - Wyeth
Ledertrexate - Wyeth, Biodim Laboratoire
Leetrexate - JohnLee Pharmaceuticals
Methoblastin - Pfizer
Methocel - Celon Laboratories
Methotrexat - Ebewe Pharma, Pliva, Teva
Methotrexate - Apotex, Ebewe Pharma, Merck, Mylan, Pfizer, Teva
Metoject - Medac, Gebro Pharma, Kampar Laboratorio, Medexus, Nordic Pharma
Metrotex - Sanofi
Mexate - Bristol-Myers Squibb, Bristol Laboratories, Cadila Pharmaceuticals
MTX - Hexal
Neotrexate - GlaxoSmithKline
Novatrex - Wyeth
Oncotrex - Sun Pharmaceutical Industries
Rheumatrex - Wyeth, Stada
Tecnomet - Zodiac Produtos Farmaceuticos
Trexall - Barr Laboratories
Trixilem - Teva, Chile Laboratorios, Elder Pharmaceuticals, Lemery, Pharmaland, Sicor Pharmaceuticals
Unitrexate - Meizler, United Biotech
References and external sources:
Methotrexate main article on Wikipedia: https://en.wikipedia.org/wiki/Methotrexate
Methotrexate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Methotrexate
Methotrexate Sodium compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Methotrexate-Sodium
Methotrexate medicine on DrugBank: https://go.drugbank.com/drugs/DB00563
Methotrexate Sodium on DrugBank: https://go.drugbank.com/salts/DBSALT000115
Methotrexate FAQ on MedlinePlus (revised 04/15/2017): https://medlineplus.gov/druginfo/meds/a682019.html
Methotrexate Injection FAQ on MedlinePlus (revised 07/15/2021): https://medlineplus.gov/druginfo/meds/a682018.html
Mylan Methotrexate tablets drug label on DailyMed (revised March 31, 2023): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Amneal Methotrexate tablets drug label on DailyMed (revised July 30, 2022): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
West-Ward Methotrexate tablets for oral use official prescribing and patient information from the U.S. FDA (revised 08/2020): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Par Pharmaceutical Methotrexate tablets for oral use official prescribing and patient information from the U.S. FDA (revised 05/2020): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Methotrexate Cipla tablets 2.5 mg, 10 mg consumer medicine information from The Therapeutic Goods Administration (revised August 2023): https://www.ebs.tga.gov.au/ebs/picmi/...
Haupt Pharma Methotrexate 2.5 mg tablets package information leaflet for patients on Medicines.org.uk (revised August 2023): https://www.medicines.org.uk/emc/files/pil.511.pdf
Revised: January 2024
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