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Product Name: Prochlorperazine
Generic Name: Prochlorperazine
Common Brands: Compazine, Prochlor. Stemzine
Pharmaceutical Categories: Antipsychotics
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Prochlorperazine (trade names include Compazine, Prochlor, Buccastem, DHAperazine, Emidoxyn, Stemzine, Nautisol, Stemetil) is a medication for disorders of nervous system from phenothiazines with piperazine structure pharmacological group. This medication helps to control severe nausea and vomiting caused by chemotherapy, radiation therapy and in the pre- and postoperative setting. It is also used to treat migraine, labyrinthitis, dizziness, vertigo, schizophrenia and in the short-term treatment of anxiety. As an antipsychotic drug prochlorperazine works by blocking dopamine receptors.
Customers also buy these medications from the same pharmacological classes:
Acetophenazine (Tindal)
Aripiprazole (Abilify)
Buspirone (Buspar)
Butaperazine (Repoise)
Chlorpromazine (Thorazine)
Clomipramine (Anafranil)
Clozapine (Clozaril)
Dixyrazine (Esucos)
Fluphenazine (Prolixin)
Lamotrigine (Lamictal)
Lithium Carbonate (Lithobid)
Loxapine (Loxitane)
Olanzapine (Zyprexa)
Perazine (Taxilan)
Perphenazine (Trilafon)
Quetiapine (Seroquel)
Risperidone (Risperdal)
Thiopropazate (Dartalan)
Thioproperazine (Majeptil)
Thioridazine (Mellaril)
Trifluoperazine (Stelazine)
Ziprasidone (Geodon)
Pharmaceutical and medical classifications:
Antipsychotic drugs
Antivertigo preparations
Anti-anxiety medications
Medicines for the treatment of schizophrenia
Phenothiazines
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N05 - Psycholeptics
N05A - Antipsychotics
N05AB - Phenothiazines with piperazine structure
N05AB04 - Prochlorperazine
Medical conditions for prochlorperazine in the International Statistical Classification of Diseases and Related Health Problems:
Schizophrenia - F20
Mood [affective] disorders - F30-F39
Other anxiety disorders - F41
Migraine - G43
Other diseases of inner ear - H83
Labyrinthitis, unspecified ear - H83.09
Nausea and vomiting - R11
Dizziness and giddiness - R42
Pregnancy category:
C - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Prochlorperazine Base
Prochlorperazine Dimaleate
Prochlorperazine Edisylate
Prochlorperazine Maleate
Prochlorperazine Mesylate
Chemical, international, and other names of this drug:
10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-
2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine
Chloperazine
Chlormeprazine
Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine [French]
Chlorperazine
N-(Gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine
Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-
Prochlorperazine Bimaleate
Prochlorperazine Mesilate
Prochloroperazine
Prochlorpemazine
Prochlorperazin
Prochlorperazinum
Prochlorperazyna
Prochlorpermazine
Prochlorpromazine
Procloperazine
Proclorperazina
Proclorperazine
Prohlorperazin
Proklooriperatsiini
Proklorperazin
Most known trade names (brands and generics) worldwide:
Antinaus - Pacific Pharmaceuticals
Anti-Naus - Sanofi
Apo-Prochlorazine - Apotex
Buccastem - Britannia Pharmaceuticals, Reckitt Benckiser
Compazine - GlaxoSmithKline
Compazine Spansule - GlaxoSmithKline
DHAperazine - Drug Houses of Australia, IDS Group, JDH Pharmaceutical, U.S. Summit
Emidoxyn - Shreya Life Sciences
Nausetil - Intas Pharmaceuticals
Nautisol - Medochemie, Komedic
Prochlor - Beacons Pharmaceuticals, Hema Laboratories, Upha Corporation
Prochlorperazine - Actavis, Alpharma, IVAX, Mylan, Sandoz, Teva, Wyeth
Scripto-Metic - Adcock Ingram
Seratil - Christo Pharmaceuticals, Polywell
Stemetil - Sanofi, DKSH, Four Star, IDS Group, Nicholas Piramal, Teofarma, Zuellig Pharma
Stemzine - Sanofi
Vometil - Cipla
Other medicines used in combinations with prochlorperazine:
Acetaminophen
Caffeine
Ergotamine Tartrate
Indometacin
Isopropamide Iodide
Neomycin Sulfate
Vitamin B6 (Pyridoxine Hydrochloride)
References and external sources:
Prochlorperazine main article on Wikipedia: https://en.wikipedia.org/wiki/Prochlorperazine
Prochlorperazine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine
Prochlorperazine Maleate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-maleate
Prochlorperazine Bimaleate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-bimaleate
Prochlorperazine Edisylate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-edisylate
Prochlorperazine Mesilate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-mesilate
Prochlorperazine medicine on DrugBank: https://www.drugbank.ca/drugs/DB00433
Prochlorperazine Maleate on DrugBank: https://www.drugbank.ca/salts/DBSALT000998
Prochlorperazine Edisylate on DrugBank: https://www.drugbank.ca/salts/DBSALT000999
Prochlorperazine FAQ on MedlinePlus (revised 02/15/2018): https://medlineplus.gov/druginfo/meds/a682116.html
Prochlorperazine Maleate tablets drug label on DailyMed (revised October 15, 2018): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Compazine (Prochlorperazine Maleate) tablets 5 mg and 10 mg, spansule capsules 10 and 15 mg, injections in vials 5 mg / ml, suppositories 2.5 mg, 5 mg, 25 mg, syrup 5 mg / 5 ml official prescribing information from the U.S. FDA (revised July 2004): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Prochlorperazine Accord 5 mg tablets patient information leaflet on Medicines.org.uk (revised August 2020): https://www.medicines.org.uk/emc/files/pil.4553.pdf
Stemzine (Prochlorperazine Maleate) 5 mg tablets patient information leaflet on Medicines.org.uk (revised 02/2021): https://www.medicines.org.uk/emc/files/pil.99.pdf
Revised: June 2021
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