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Product Name: Chlorpromazine
Generic Name: Chlorpromazine
Common Brands: Emetil, Largactil, Thorazine
Pharmaceutical Categories: Antipsychotics
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Chlorpromazine (trade names include Thorazine, Largactil, Emetil, Amplictil, Aminazin, Longactil, Plegomazin, Taroctyl, Promactil, Teva-Chlorpromazine) is an antipsychotic medication from phenothiazines with aliphatic side-chain pharmacological group. This medicine is used to treat certain mental, behavioral, psychotic disorders such as anxiety, schizophrenia, acute and chronic psychosis, amphetamine-induced psychosis, psychotic aggression, manic-depressive illness, bipolar disorder, severe behavioral problems in children including attention deficit hyperactivity disorder; to control nausea and vomiting, nervousness and anxiety before surgery, hiccups that will not go away, symptoms of delirium in hospitalized AIDS patients, porphyria episodes, tetanus (in combination with other medications), in veterinary medicine. It is also off-label indicated for the therapy of severe migraine, symptomatic hypertensive emergency, insomnia, severe pruritus, for preanesthesia, to reduce nausea by opioid-treated cancer patients, to intensify and prolong the analgesia of the opioids. Chlorpromazine HCl works as a very effective antagonist of D2 dopamine and similar receptors.
Customers also buy these medications from the same pharmacological classes:
Acepromazine (Plegicil)
Aripiprazole (Abilify)
Atomoxetine (Strattera)
Buspirone (Buspar)
Chlorproethazine (Neuriplege)
Clomipramine (Anafranil)
Clozapine (Clozaril)
Cyamemazine (Tercian)
Divalproex (Depakote)
Haloperidol (Haldol)
Lamotrigine (Lamictal)
Levomepromazine (Nozinan)
Lithium Carbonate (Lithobid)
Loxapine (Loxitane)
Lurasidone (Latuda)
Melatonin (Meloset)
Olanzapine (Zyprexa)
Paroxetine (Paxil)
Piracetam (Nootropil)
Prochlorperazine (Compazine)
Promazine (Phenergan)
Quetiapine (Seroquel)
Risperidone (Risperdal)
Thioridazine (Mellaril)
Triflupromazine (Vesprin)
Venlafaxine (Effexor)
Ziprasidone (Geodon)
Pharmaceutical and medical classifications:
Alpha1- and alpha2-adrenergic receptors antagonists
Anti anxiety medications
Anti migraine drugs
Anti nausea tablets
Anxiolytics
Dopamine receptors antagonists
H1 histamine receptors antagonists
Hypnotics and sedatives
M1 and M2 muscarinic acetylcholine receptors antagonists
Neuroleptics
Serotonin receptors antagonists
Sleep aid pills
Typical antipsychotics
Veterinary, pet meds
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N05 - Psycholeptics
N05A - Antipsychotics
N05AA - Phenothiazines with aliphatic side-chain
N05AA01 - Chlorpromazine
Medical conditions for chlorpromazine in the International Statistical Classification of Diseases and Related Health Problems:
Tetanus neonatorum - A33
Obstetrical tetanus - A34
Other tetanus - A35
Human immunodeficiency virus [HIV] disease - B20
Neoplasms - C00-D49
Disorders of porphyrin and bilirubin metabolism - E80
Unspecified porphyria - E80.20
Delirium due to known physiological condition - F05
Other mental disorders due to known physiological condition - F06
Psychotic disorder with delusions due to known physiological condition - F06.2
Other stimulant related disorders - F15
Schizophrenia, schizotypal and delusional disorders - F20-F29
Schizophrenia - F20
Schizotypal disorder - F21
Brief psychotic disorder - F23
Unspecified psychosis not due to a substance or known physiological condition - F29
Bipolar disorder - F31
Anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders - F40-F48
Phobic anxiety disorders - F40
Fear of other medical care - F40.232
Other anxiety disorders - F41
Attention-deficit hyperactivity disorders - F90
Other behavioral and emotional disorders with onset usually occurring in childhood and adolescence - F98
Migraine - G43
Sleep disorders - G47
Insomnia - G47.0
Hypertensive crisis - I16
Hypertensive emergency - I16.1
Pruritus - L29
Abnormalities of breathing - R06
Hiccough, hiccups - R06.6
Nausea and vomiting - R11
Encounter for other special examination without complaint, suspected or reported diagnosis - Z01
Encounter for other preprocedural examination - Z01.818
Pregnancy category:
C - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Chlorpromazine Base
Chlorpromazine Embonate
Chlorpromazine Hibenzate
Chlorpromazine Hydrochloride
Chlorpromazine Maleate
Chlorpromazine Sulfone
Chlorpromazine Sulfoxide
Chemical, international, and other names of this drug:
10-(3-Dimethylaminopropyl)-2-chlorophenothiazine
2-Chloro-10-(3-(dimethylamino)propyl)-phenothiazine
Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine
Chloorpromazine
Chloropromazyna
Chloropromazine
Chlorpromados
Chlorpromazin
Chlorpromazinium
Chlorpromazinum
Clorpromazina
CPZ
Hlorpromazin
Klooripromatsiini
Klorpromazin
N-(3-Dimethylaminopropyl)-3-Chlorophenothiazine
Phenothiazine, 2-Chloro-10-(3-(dimethylamino)propyl)-
Most known trade names (brands and generics) worldwide:
Aminazin - Akrikhin, Pharbaco, Pharmstandard-Polypharm
Aminazine - Akrikhin
Amplictil - Sanofi
Chloractil - DDSA Pharmaceuticals
Chlorpromazine - Abbott, Alpharma, Dr. Reddy's Laboratories, Sandoz, Sun Pharmaceutical Industries, Watson Pharmaceuticals, Wyeth
Clorpromazina - Biosano Laboratorios, Pasteur Laboratorios, Rider Laboratorios
Emetil - LA Pharmaceuticals
Laractyl - Patriot Pharmaceuticals
Largactil - Sanofi, Abbott, Hawgreen, Teofarma, Vitoria Laboratorios
Longactil - Cristalia Produtos Quimicos Farmaceuticos
Matcine - Atlantic Laboratories
Megaphen - Bayer
Megatil - Intas Pharmaceuticals
Plegomazin - Egis
Promactil - Combiphar
Promazine - Atlantic Laboratories
Prozin - Istituto Luso Farmaco d'Italia
Solidon - Adelco Chromatourgia Athinon, E. Colocotronis Bros.
Taroctyl - Taro Pharmaceutical Industries
Teva-Chlorpromazine - Teva
Thorazine - GlaxoSmithKline
Other medicines used in combinations with chlorpromazine:
Amobarbital
Chlorcyclizine
Cineole
Citiolone
Dextromethorphan
Dyphylline
Guaifenesin
Heptaminol
Imipramine
Niaouli Oil
Procaine
Scopolamine
Trifluoperazine
Trihexyphenidyl
Vitamin B6 (Pyridoxine Hydrochloride)
References and external sources:
Chlorpromazine main article on Wikipedia: https://en.wikipedia.org/wiki/Chlorpromazine
Chlorpromazine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpromazine
Chlorpromazine Hydrochloride on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/chlorpromazine%20HCl
Chlorpromazine medicine on DrugBank: https://go.drugbank.com/drugs/DB00477
Chlorpromazine Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000026
Chlorpromazine FAQ on MedlinePlus (revised 07/15/2017): https://medlineplus.gov/druginfo/meds/a682040.html
Chlorpromazine overdose information on MedlinePlus (revised 07/01/2023): https://medlineplus.gov/ency/article/002608.htm
Amneal Chlorpromazine Hydrochloride film-coated tablets drug label on DailyMed (revised December 29, 2023): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Hikma Chlorpromazine Hydrochloride injections drug label on DailyMed (revised April 8, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Largactil (Chlorpromazine Hydrochloride) drops, suppositories, liquid prescribing and consumer information from The Drug and Health Product Register (revised October 13, 2006): https://pdf.hres.ca/dpd_pm/00002958.PDF
Largactil (Chlorpromazine Hydrochloride) tablets, syrup, injection product information from The Therapeutic Goods Administration (revised 10 October 2023): https://www.ebs.tga.gov.au/ebs/picmi/...
Largactil (Chlorpromazine Hydrochloride) tablets, syrup, injection consumer medicine information from NPS MedicineWise (revised October 2023): https://www.nps.org.au/assets/medicines/...
Dr. Reddy's Chlorpromazine 25 mg, 50 mg, 100 mg tablets package information leaflet for users on Medicines.org.uk (revised 11/2023): https://www.medicines.org.uk/emc/files/pil.3475.pdf
Revised: July 2024
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