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Product Name: Valproic Acid
Generic Name: Valproic Acid
Common Brands: Depakene, Depakine, Depakote
Pharmaceutical Categories: Antiepileptic drugs, Anticonvulsants
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Valproic Acid (VPA, Sodium Valproate, Divalproex Sodium) - trade names include Depakote, Depakene, Epilenil, Stavzor, Apo-Divalproex, Depakin, Depakine Chrono, Depakine Chrono Retard, Depakote Sprinkle, Deprakine, Teva-Divalproex, Valance-OD, Epival, Delepsine, Depakine Enteric, Depalept, Epilim Chrono, Ergenyl, Micropakine LP, Natriumvalproaat Chrono, Orfiril, Valpakine, Valparin, Valproat Neuraxpharm, Valproat Chrono, Valproate de Sodium, Convulex, Depalept Chrono, Encorate Chrono, Epilex Chrono, Valparin Chrono - is an anticonvulsant (antiepileptic) medication from fatty acid derivatives pharmacological group. This medicine is indicated to prevent seizures caused by some forms of epilepsy and to treat various types of seizure disorders such as tonic-clonic seizures, absence seizures, myoclonic seizures, partial and multiple seizures, infantile spasms, status epilepticus. Depakote is also indicated for the treatmnet of manic phase of bipolar disorders (manic-depressive illness), hyperekplexia, cluster-tic syndrome, to prevent migraine headaches, as an add-on for people with schizophrenia, schizoaffective disorder, for controlling the symptoms of the dopamine dysregulation syndrome. Valproic Acid, its salts and derivatives are also off-label used for sedative purposes, for learning absolute pitch.
Related medications:
Aripiprazole (Abilify)
Atomoxetine (Strattera)
Buspirone (Buspar)
Carbamazepine (Tegretol)
Carbidopa, Levodopa (Sinemet)
Chlorpromazine (Thorazine)
Clomipramine (Anafranil)
Clozapine (Clozaril)
Gabapentin (Neurontin)
Lamotrigine (Lamictal)
Levetiracetam (Keppra)
Loxapine (Loxitane)
Olanzapine (Zyprexa)
Oxcarbazepine (Trileptal)
Phenytoin (Dilantin)
Pramipexole (Mirapex)
Pregabalin (Lyrica)
Primidone (Mysoline)
Progabide (Gabrene)
Quetiapine (Seroquel)
Risperidone (Risperdal)
Rizatriptan (Maxalt)
Sumatriptan (Imitrex)
Tiagabine (Gabitril)
Thioridazine (Mellaril)
Topiramate (Topamax)
Valpromide (Depamide)
Vigabatrin (Sabril)
Ziprasidone (Geodon)
Pharmaceutical and medical classifications:
Anticonvulsants
Antiepileptic agents
Antimigraine drugs
Antipsychotics
Fatty acid derivative anticonvulsants
Valproic Acid derivatives
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N03 - Antiepileptics
N03A - Antiepileptics
N03AG - Fatty acid derivatives
N03AG01 - Valproic Acid
Medical conditions for valproic acid in the International Statistical Classification of Diseases and Related Health Problems (ICD):
Schizophrenia - F20
Schizoaffective disorders - F25
Manic episode - F30
Bipolar disorder - F31
Persistent mood [affective] disorders - F34
Disruptive mood dysregulation disorder - F34.81
Specific developmental disorders of scholastic skills - F81
Tic disorders - F95
Other extrapyramidal and movement disorders - G25
Myoclonus - G25.3
Epilepsy and recurrent seizures - G40
Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures - G40.1
Generalized idiopathic epilepsy and epileptic syndromes - G40.3
Other epilepsy and recurrent seizures - G40.8
Epileptic spasms, not intractable, without status epilepticus - G40.822
Epilepsy, unspecified, not intractable - G40.90
Absence epileptic syndrome - G40.A
Migraine - G43
Other headache syndromes - G44
Other congenital malformations, not elsewhere classified - Q89
Other specified congenital malformations - Q89.8
Abnormal involuntary movements - R25
Headache - R51
Pregnancy category:
D - Australia
D - United States (Positive evidence of risk)
Forms of active pharmaceutical ingredients (APIs):
Divalproex Sodium
Valproate Magnesium
Valproate Calcium
Valproate Semisodium
Valproate Sodium
Valproic Acid
Chemical, international, and other names of this drug:
(S)-2-Propyl-4-pentanoic Acid
2-Propylpentanoic Acid
2-Propylvaleric Acid
4-Heptanecarboxylic Acid
4-Pentanoic Acid, 2-Propyl-, (S)-
Acetic Acid, Dipropyl-
Acid Valproic
Acide Valproique
Acido Valproico
Acidum Valproicum
Azido Balproiko
Di-N-Propylacetic Acid
Di-N-Propylessigsaure
Dipropylacetate
Dipropylacetic Acid
Divalproex
Kwas Walproinowy
Kyselina 2-Propylvalerova
Natrii Valproas
Natriumvalproat
N-Dipropylacetic Acid
N-DPA
Pentanoic Acid, 2-Propyl-
Propylvaleric Acid
S(-)-4-En-Valproic Acid
S-2-N-Propyl-4-Pentenoic Acid
Sodium Hydrogen Divalproate
Valeric Acid, 2-Propyl-
Valproat
Valproate
Valproato
Valproato de Magnesio
Valproatum
Valproic Acid
Valproico Acido
Valproicum Acidum
Valproinezuur
Valproinsaure
Valproinsav
Valproinska Kiselina
Valproinsyra
Valproique Acide
Most known trade names (brands and generics) worldwide:
Absenor - Orion Pharma
Apo-Divalproex - Apotex
Atemperator - Drugtech Laboratorio
Atemperator LP - Armstrong Laboratorios de Mexico
Convulex - Pfizer, Altana Pharma, Gerot Pharmazeutika, Lannacher Heilmittel, Lundbeck, Orion Pharma, R.P. Scherer
Convulsofin - AWD Pharma, Asta Medica, Klocke Pharma-Service, Menarini, Pharma Wernigerode, Pliva
Delepsine - Orion Pharma
Depakene - Sanofi, Abbott
Depakin - Sanofi
Depakine - Sanofi, Abbott
Depakine Chrono - Sanofi
Depakine Chrono Retard - Sanofi
Depakine Chronosphere - Sanofi
Depakine Enteric - Sanofi
Depakote - Abbott, AbbVie, Sanofi
Depakote ER - Abbott, AbbVie
Depakote Sprinkle Capsules - Abbott, AbbVie
Depalept - Sanofi, C.T.S. Chemical Industries
Depalept Chrono - Sanofi, C.T.S. Chemical Industries
Depamag - Sigma-Tau Pharmaceuticals
Deprakine - Sanofi
Desval-ER - Ranbaxy
Dicorate-ER - Sun Pharmaceutical Industries
Diplexil - Tecnifar
Divaa - Intas Pharmaceuticals
Divalproex - Aurobindo Pharma, Genpharm, Mylan, Pro Doc, Sandoz, Teva, Watson Pharmaceuticals, Wockhardt
Encorate Chrono - Sun Pharmaceutical Industries, Pharmaland 1982
Epilenil - Biolab Sanus Farmaceutica
Epilex Chrono - Abbott
Epilim - Sanofi
Epilim Chrono - Sanofi, DKSH, IDS Group, The Glory Medicina, Zuellig Pharma
Episenta - Beacon Pharmaceuticals
Epival - Abbott, Gerot Pharmazeutika, Zuellig Pharma
Epival ER - Abbott
Epival Sprinkle - Abbott
Ergenyl - Sanofi, F. Joh. Kwizda
Ergenyl Chrono - Sanofi
Exibral - Bago Laboratorios
Macorate - Sun Pharmaceutical Industries
Micropakine - Sanofi
Micropakine L.P. - Sanofi
Natriumvalproaat - Sandoz
Natriumvalproaat Chrono - Sandoz
Neuractin - Drugtech Laboratorio
Novo-Divalproex - Novopharm
Orfiril - Desitin Arzneimittel, Algol Pharma, Ewopharma, Jacobson Medical, Megapharm, Israel, Ranbaxy, Zyfas Medical
Orfiril Long - Desitin Arzneimittel, Pharmaniaga, Ranbaxy
Orfiril Retard - Desitin Arzneimittel, Ranbaxy, Zyfas Medical
Orlept - Wockhardt
Stavzor - Banner Pharmacaps, Noven Pharmaceuticals
Torvate - Torrent Pharmaceuticals
Trend-XR - Torrent Pharmaceuticals
Valance-OD - Abbott
Valcote - Abbott
Valcote Sprinkle - Abbott
Valpakine - Sanofi
Valparin - Sanofi, Torrent Pharmaceuticals, Union Medical
Valparin Chrono - Sanofi
Valparin XR - Torrent Pharmaceuticals, Metro Drug Distribution, Zyfas Medical
Valprid - Micro Labs
Valpro - Alphapharm, Betapharm Arzneimittel, TAD Pharma
Valproat - Azupharma, Neuraxpharm Arzneimittel
Valproat - Sandoz
Valproat Chrono - Desitin Arzneimittel
Valproate - Aguettant, APP Pharmaceuticals, Bedford Laboratories
Valproate de Sodium - Arrow Generiques, Biogaran, Merck, Mylan, Ranbaxy, Ratiopharm, Sandoz, Sanofi, Teva
Valproic Acid - Hi Tech Pharmaceuticals, Sun Pharmaceutical Industries, Teva, Vintage Pharmaceuticals
Valprol-CR - Intas Pharmaceuticals
References and external sources:
Valproate main article on Wikipedia: https://en.wikipedia.org/wiki/Valproate
Valproic Acid compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Valproic-Acid
Valproate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Valproate
Valproic Acid medicine on DrugBank: https://go.drugbank.com/drugs/DB00313
Valproate Sodium medicine on DrugBank: https://go.drugbank.com/salts/DBSALT001257
Valproic Acid FAQ on MedlinePlus (revised 04/15/2019): https://medlineplus.gov/druginfo/meds/a682412.html
Depakote (Divalproex Sodium) delayed-release tablets drug label on DailyMed (revised April 2, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Depakote ER (Divalproex Sodium) extended-release tablets drug label on DailyMed (revised March 18, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Bionpharma Valproic Acid capsules drug label on DailyMed (revised April 3, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Depakote (Divalproex Sodium) delayed-release tablets for oral use official prescribing information and medication guide from the U.S. FDA (revised 05/2020): https://www.accessdata.fda.gov/drugsatfda_docs/label/...
Depakote ER (Divalproex Sodium) extended-release tablets for oral use official prescribing information and medication guide from the U.S. FDA (revised 02/2023): https://www.accessdata.fda.gov/drugsatfda_docs/label/...
Depakote, Depakote ER, Depakote Sprinkle Capsules (Divalproex Sodium) official website powered by AbbVie pharmaceutical company: https://www.depakote.com/
Depakote (Divalproex Sodium) official website for U.S. healthcare professionals powered by AbbVie: https://www.depakotehcp.com/
Sodium Valproate Sandoz consumer medicine information from NPS MedicineWise (revised September 2022): https://www.nps.org.au/assets/medicines/...
Epilim (Sodium Valproate) tablets, enteric-coated tablets, syrup, liquid product information from The Therapeutic Goods Administration (revised 12 March 2024): https://www.ebs.tga.gov.au/ebs/picmi/...
Depakote (Valproate Semisodium) 250 mg and 500 mg tablets patient information leaflet for users from Medicines.org.uk (revised September 2023): https://www.medicines.org.uk/emc/files/pil.6102.pdf
Revised: April 2024
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