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Product Name: Prochlorperazine
Generic Name: Prochlorperazine
Common Brands: Compazine, Prochlor. Stemzine
Pharmaceutical Categories: Antipsychotics

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  • Prochlorperazine (trade names include Compazine, Prochlor, Buccastem, DHAperazine, Emidoxyn, Stemzine, Nautisol, Stemetil) is a medication for disorders of nervous system from phenothiazines with piperazine structure pharmacological group. This medication helps to control severe nausea and vomiting caused by chemotherapy, radiation therapy and in the pre- and postoperative setting. It is also used to treat migraine, labyrinthitis, dizziness, vertigo, schizophrenia and in the short-term treatment of anxiety. As an antipsychotic drug prochlorperazine works by blocking dopamine receptors.


    Compazine (Prochlorperazine Maleate) tablets USP


    Customers also buy these medications from the same pharmacological classes:

  • Acetophenazine (Tindal)
  • Aripiprazole (Abilify)
  • Buspirone (Buspar)
  • Butaperazine (Repoise)
  • Chlorpromazine (Thorazine)
  • Clomipramine (Anafranil)
  • Clozapine (Clozaril)
  • Dixyrazine (Esucos)
  • Fluphenazine (Prolixin)
  • Lamotrigine (Lamictal)
  • Lithium Carbonate (Lithobid)
  • Loxapine (Loxitane)
  • Olanzapine (Zyprexa)
  • Perazine (Taxilan)
  • Perphenazine (Trilafon)
  • Quetiapine (Seroquel)
  • Risperidone (Risperdal)
  • Thiopropazate (Dartalan)
  • Thioproperazine (Majeptil)
  • Thioridazine (Mellaril)
  • Trifluoperazine (Stelazine)
  • Ziprasidone (Geodon)


    Pharmaceutical and medical classifications:

  • Antipsychotic drugs
  • Antivertigo preparations
  • Anti-anxiety medications
  • Medicines for the treatment of schizophrenia
  • Phenothiazines


    The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):

  • N - Nervous system
  • N05 - Psycholeptics
  • N05A - Antipsychotics
  • N05AB - Phenothiazines with piperazine structure
  • N05AB04 - Prochlorperazine


    Medical conditions for prochlorperazine in the International Statistical Classification of Diseases and Related Health Problems:

  • Schizophrenia - F20
  • Mood [affective] disorders - F30-F39
  • Other anxiety disorders - F41
  • Migraine - G43
  • Other diseases of inner ear - H83
  • Labyrinthitis, unspecified ear - H83.09
  • Nausea and vomiting - R11
  • Dizziness and giddiness - R42


    Pregnancy category:

  • C - Australia
  • C - United States (Risk cannot be ruled out)


    Forms of active pharmaceutical ingredients (APIs):

  • Prochlorperazine Base
  • Prochlorperazine Dimaleate
  • Prochlorperazine Edisylate
  • Prochlorperazine Maleate
  • Prochlorperazine Mesylate


    Chemical, international, and other names of this drug:

  • 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-
  • 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine
  • Chloperazine
  • Chlormeprazine
  • Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine [French]
  • Chlorperazine
  • N-(Gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine
  • Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-
  • Prochlorperazine Bimaleate
  • Prochlorperazine Mesilate
  • Prochloroperazine
  • Prochlorpemazine
  • Prochlorperazin
  • Prochlorperazinum
  • Prochlorperazyna
  • Prochlorpermazine
  • Prochlorpromazine
  • Procloperazine
  • Proclorperazina
  • Proclorperazine
  • Prohlorperazin
  • Proklooriperatsiini
  • Proklorperazin


    Most known trade names (brands and generics) worldwide:

  • Antinaus - Pacific Pharmaceuticals
  • Anti-Naus - Sanofi-Aventis
  • Apo-Prochlorazine - Apotex
  • Buccastem - Britannia Pharmaceuticals, Reckitt Benckiser
  • Compazine - GlaxoSmithKline
  • Compazine Spansule - GlaxoSmithKline
  • DHAperazine - Drug Houses of Australia, IDS Group, JDH Pharmaceutical, U.S. Summit
  • Emidoxyn - Shreya Life Sciences
  • Nausetil - Intas Pharmaceuticals
  • Nautisol - Medochemie, Komedic
  • Prochlor - Beacons Pharmaceuticals, Hema Laboratories, Upha Corporation
  • Prochlorperazine - Actavis, Alpharma, IVAX, Mylan, Sandoz, Teva, Wyeth
  • Scripto-Metic - Adcock Ingram
  • Seratil - Christo Pharmaceuticals, Polywell
  • Stemetil - Sanofi-Aventis, DKSH, Four Star, IDS Group, Nicholas Piramal, Teofarma, Zuellig Pharma
  • Stemzine - Sanofi-Aventis
  • Vometil - Cipla


    Other medicines used in combinations with prochlorperazine:

  • Acetaminophen
  • Caffeine
  • Ergotamine Tartrate
  • Indometacin
  • Isopropamide Iodide
  • Neomycin Sulfate
  • Vitamin B6 (Pyridoxine Hydrochloride)


    References and external sources:

  • Prochlorperazine main article on Wikipedia: https://en.wikipedia.org/wiki/Prochlorperazine
  • Prochlorperazine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine
  • Prochlorperazine Maleate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-maleate
  • Prochlorperazine Bimaleate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-bimaleate
  • Prochlorperazine Edisylate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-edisylate
  • Prochlorperazine Mesilate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Prochlorperazine-mesilate
  • Prochlorperazine medicine on DrugBank: https://www.drugbank.ca/drugs/DB00433
  • Prochlorperazine Maleate on DrugBank: https://www.drugbank.ca/salts/DBSALT000998
  • Prochlorperazine Edisylate on DrugBank: https://www.drugbank.ca/salts/DBSALT000999
  • Prochlorperazine FAQ on MedlinePlus (revised 02/15/2018): https://medlineplus.gov/druginfo/meds/a682116.html
  • Prochlorperazine Maleate tablets drug label on DailyMed (revised October 15, 2018): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Compazine (Prochlorperazine Maleate) tablets 5 mg and 10 mg, spansule capsules 10 and 15 mg, injections in vials 5 mg / ml, suppositories 2.5 mg, 5 mg, 25 mg, syrup 5 mg / 5 ml official prescribing information from the U.S. FDA (revised July 2004): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Prochlorperazine Accord 5 mg tablets patient information leaflet on Medicines.org.uk (revised August 2020): https://www.medicines.org.uk/emc/files/pil.4553.pdf
  • Stemzine (Prochlorperazine Maleate) 5 mg tablets patient information leaflet on Medicines.org.uk (revised 02/2021): https://www.medicines.org.uk/emc/files/pil.99.pdf

    Revised: June 2021



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