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Product Name: Duloxetine
Generic Name: Duloxetine
Common Brands: Cymbalta
Pharmaceutical Categories: Antidepressants, Anti Anxiety
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Duloxetine (trade names include Cymbalta, Andepra, Apo-Duloxetine, Ariclaim, Cymgen, Dulane, Duloxetine-DR, Dulsevia, Duxet, Duzac, Duzela, Teva-Duloxetine, Xeristar, Yelate, Yentreve) is an antidepressant from serotonin and noradrenaline reuptake inhibitors (SNRIs) pharmacological group. This medicine is used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, mood disorders, central sensitization, neuropathic pain, fibromyalgia. Duloxetine is also indicated for the treatment of diabetic peripheral neuropathy, chemotherapy-induced neuropathy, chronic musculoskeletal pain, stress urinary incontinence, chronic pain caused by complications of diabetes or pain caused by fibromyalgia. It works by affecting chemicals in the brain that may become unbalanced and cause depression.
Customers also buy these medications from the same pharmacological classes:
Agomelatine (Valdoxan)
Amitriptyline (Elavil)
Bifemelane (Alnert)
Brexanolone (Zulresso)
Bupropion, Dextromethorphan (Auvelity)
Bupropion (Wellbutrin, Zyban)
Citalopram (Celexa)
Clomipramine (Anafranil)
Desvenlafaxine (Pristiq)
Doxepin (Sinequan)
Escitalopram (Lexapro)
Esketamine (Spravato)
Fluvoxamine (Luvox)
Gepirone (Variza)
Imipramine (Tofranil)
Levomilnacipran (Fetzima)
Medifoxamine (Cledial)
Mianserin (Tolvon)
Milnacipran (Savella)
Minaprine (Isopulsan)
Mirtazapine (Remeron)
Nefazodone (Nefadar)
Nomifensine (Linamiphen)
Nortriptyline (Aventyl, Pamelor)
Oxaflozane (Conflictan)
Oxitriptan (Triptene)
Paroxetine (Paxil)
Pivagabine (Tonerg)
Reboxetine (Edronax)
Tianeptine (Stablon)
Trazodone (Desyrel)
Venlafaxine (Effexor)
Vilazodone (Viibryd)
Viloxazine (Vivalan)
Vortioxetine (Trintellix)
Pharmaceutical and medical classifications:
Anti anxiety medicines
Antidepressants
Analgesics
Pain relief medications
Serotonin-norepinephrine reuptake inhibitors (SNRI)
Urological drugs
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N06 - Psychoanaleptics
N06A - Antidepressants
N06AX - Other antidepressants
N06AX21 - Duloxetine
Medical conditions for duloxetine in the International Statistical Classification of Diseases and Related Health Problems:
Type 2 diabetes mellitus - E11
Type 2 diabetes mellitus with neurological complications - E11.4
Mood [affective] disorders - F30-F39
Major depressive disorder, single episode - F32
Major depressive disorder, recurren - F33
Other anxiety disorders - F41
Generalized anxiety disorder - F41.1
Obsessive-compulsive disorder - F42
Other and unspecified polyneuropathies - G62
Drug-induced polyneuropathy - G62.0
Pain, not elsewhere classified - G89
Central pain syndrome - G89.0
Other and unspecified soft tissue disorders, not elsewhere classified - M79
Myalgia - M79.1
Neuralgia and neuritis, unspecified - M79.2
Fibromyalgia - M79.7
Other disorders of urinary system - N39
Stress incontinence (female) (male) - N39.3
Other symptoms and signs involving the nervous and musculoskeletal systems - R29
Unspecified symptoms and signs involving the musculoskeletal system - R29.91
Pregnancy category:
B3 - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Duloxetine Base
Duloxetine Hydrochloride
Chemical, international, and other names of this drug:
(R)-Duloxetine
(S)-Duloxetine
(S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine
2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (S)-
Cloridrato de Duloxetina
Dulaxetine
Duloksetin
Duloksetiini
Duloksetyna
Duloxetin
Duloxetinhydrochlorid
Duloxetina Clorhidrato
Duloxetine HCl
Duloxetini Hydrochloridum
Duloxetinum
Most known trade names (brands and generics) worldwide:
Alacir - Roemmers Laboratorios
Andepra - Aspen
Apo-Duloxetine - Apotex
Ariclaim - Eli Lilly, Boehringer Ingelheim
Cymbalta - Eli Lilly, Aspen, Boehringer Ingelheim, DKSH, Four Star, Icepharma, Phadisco, Shionogi & Co., Y.C. Woo, Zuellig Pharma
Cymgen - Eli Lilly
Delok - Abbott, Nicholas Piramal India
DLX - Solitaire Pharmacia
Duceten - Drugtech Laboratorio, Recalcine Laboratorios
Dulane - Sun Pharmaceutical Industries
Dulot - Lupin Pharmaceuticals
Dulotin - Mesmer Pharmaceuticals, Icon Life Sciences
Duloxetin - Betapharm Arzneimittel, Merckle, Ratiopharm
Duloxetina - Dr. Reddy's Laboratories, Pensa Pharma, Saval Laboratorios
Duloxetine - Actavis, Biogaran, Eli Lilly, Generics UK, KRKA, Sandoz, TAD Pharma, Teva
Duloxetine-DR - Teva
Dulsevia - KRKA
Dupact - Wockhardt
Duxet - Nobel Ilac
Duzac - Sun Pharmaceutical Industries
Duzela - Sun Pharmaceutical Industries, S.J. & G. Fazul Ellahie
DXT - Reliance Drugs & Surgicals
Nexetin - Nobel Ilac
Nitexol - Andromaco Laboratorios, ABL Pharma
Nitidex - IVAX
Sympta - Ipca Laboratories
Teva-Duloxetine - Teva
Velija - Libbs Farmaceutica
Xeristar - Eli Lilly, Boehringer Ingelheim, Dr. Esteve Laboratorios
Yelate - Dr. Reddy's Laboratories
Yentreve - Eli Lilly, Boehringer Ingelheim, Shrooq Pharmaceuticals
Other medicines used in combinations with duloxetine:
Avanafil
Methylcobalamin
Sildenafil
References and external sources:
Duloxetine main article on Wikipedia: https://en.wikipedia.org/wiki/Duloxetine
Duloxetine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/60835
Duloxetine Hydrochloride on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Duloxetine-hydrochloride
Duloxetine medicine on DrugBank: https://go.drugbank.com/drugs/DB00476
Duloxetine Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000378
Duloxetine FAQ on MedlinePlus (revised 03/15/2022): https://medlineplus.gov/druginfo/meds/a604030.html
Cymbalta (Duloxetine Hydrochloride) capsules delayed-release drug label on DailyMed (revised August 18, 2023): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Direct Rx Duloxetine capsules delayed-release drug label on DailyMed (revised January 12, 2023): https://dailymed.nlm.nih.gov/dailymed/lookup...
Teva-Duloxetine capsules delayed-release drug label on DailyMed (revised November 30, 2023): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Cymbalta (Duloxetine Hydrochloride) delayed-release capsules for oral use official prescribing information and medication guide from the U.S. FDA (revised 04/2020): https://www.accessdata.fda.gov/drugsatfda_docs/label/...
Cymbalta (Duloxetine Hydrochloride) delayed-release capsules for oral use prescribing information from Eli Lilly pharmaceutical company (revised 08/2023): https://pi.lilly.com/us/cymbalta-pi.pdf
Cymbalta (Duloxetine Hydrochloride) delayed-release capsules medication guide from Eli Lilly (revised 08/2023): http://pi.lilly.com/us/Cymbalta-Medguide.pdf
Ariclaim (Duloxetine) product information from European Medicines Agency: https://www.ema.europa.eu/en/medicines/human/EPAR/ariclaim
Cymbalta (Duloxetine Hydrochloride) 30 mg, 60 mg hard gastro-resistant capsules package information leaflet for users from Medicines.org.uk (revised January 2021): https://www.medicines.org.uk/emc/files/pil.3880.pdf
Revised: May 2024
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