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Product Name: Tizanidine
Generic Name: Tizanidine
Common Brands: Zanaflex
Pharmaceutical Categories: Pain Relief, Muscle Relaxants
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Tizanidine (trade names include Zanaflex, Sirdalud, Ternelin, Tizan, Tizanidin Teva, Tizanidine Arrow, Tizanor, Tizpa) is a short-acting muscle relaxer from centrally acting muscle relaxants pharmacological group. This medicine is used for the treatment of muscle spasms, cramping, tightness of muscles caused by some diseases and medical conditions, such as muscle spasticity, spastic diplegia, multiple sclerosis, spastic cerebral palsy, amyotrophic lateral sclerosis (ALS), back pain, spinal cord injury, other injuries to the spine or CNS. It is also indicated to treat migraine headaches, cluster headaches, some symptoms of fibromyalgia, as an anticonvulsant, as a sleep aid medication. Tizanidine HCl works by blocking nerve impulses (pain sensations) that are sent to your brain.
Customers also buy these medications from the same pharmacological classes:
Azathioprine (Imuran)
Baclofen (Lioresal)
Bisacodyl (Dulcolax)
Butylscopolamine (Buscopan)
Carbamazepine (Tegretol)
Carisoprodol (Soma)
Chlorzoxazone (Parafon)
Cilostazol (Pletal)
Cyclobenzaprine (Flexeril)
Diclofenac (Voltaren)
Eperisone (Myonal)
Fenyramidol (Anabloc)
Flavoxate (Urispas)
Mebeverine (Colospa)
Mefenamic Acid (Ponstel)
Mephenesin (Decontractil)
Metaxalone (Skelaxin)
Methocarbamol (Robaxin)
Milnacipran (Savella)
Nabumetone (Relafen)
Nimodipine (Nimotop)
Pridinol (Lyseen)
Probenecid (Benemid, Probalan)
Pyridostigmine (Mestinon)
Ropinirole (Requip)
Sumatriptan (Imitrex)
Tetrazepam (Myolastan)
Thiocolchicoside (Muscoril)
Tolperisone (Mydeton)
Pharmaceutical and medical classifications:
Alpha2-adrenergic receptor agonists
Analgesics
Anti migraine medications
Anticonvulsants
Antispasmodic drugs
Centrally acting skeletal muscle relaxants
Muscle relaxers
Pain relief drugs
Sleep aid pills
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
M - Musculo-skeletal system
M03 - Muscle relaxants
M03B - Muscle relaxants, centrally acting agents
M03BX - Other centrally acting agents
M03BX02 - Tizanidine
Medical conditions for tizanidine in the International Statistical Classification of Diseases and Related Health Problems:
Spinal muscular atrophy and related syndromes - G12
Amyotrophic lateral sclerosis - G12.21
Multiple sclerosis - G35
Epilepsy and recurrent seizures - G40
Migraine - G43
Other headache syndromes - G44
Cluster headache syndrome, unspecified - G44.00
Sleep disorders - G47
Cerebral palsy - G80
Spastic diplegic cerebral palsy - G80.1
Hemiplegia - G81
Paraplegia and tetraplegia - G82
Other diseases of spinal cord - G95
Dorsalgia - M54
Other and unspecified soft tissue disorders, not elsewhere classified - M79
Fibromyalgia - M79.7
Other disorders of muscle - M62
Muscle spasm - M62.83
Abnormal involuntary movements - R25
Injury of nerves and spinal cord at thorax level - S24
Pregnancy category:
C - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Tizanidine Base
Tizanidine Hydrochloride
Chemical, international, and other names of this drug:
2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
Tisanidine
Titsanidiini
Tizanidin
Tizanidina
Tizanidine HCL
Tizanidinhydrochlorid
Tinazidini Hydrochloridum
Tizanidinum
Tizanidyna
Most known trade names (brands and generics) worldwide:
Apo-Tizanidine - Apotex
Flexitine - Behrens Laboratorio
Miorelax - Bioquifar Pharmaceutica
Movax - Sami Pharmaceuticals
Musant - Niche Generics
Musidin - Martin Dow Pharmaceuticals
Mylan-Tizanidine - Mylan
Myores - Meprofarm
Myos-Nor - Best Laboratorios
Phardex - Pharos Chemie
Sirdalud - Novartis, DKSH, Dr. Reddy's Laboratories, Eurim-Pharm, Laus Farma, Paranova Danmark, San Giorgio Pharma, Sandoz, Sanofi, Zuellig Pharma
Sirdalud Retard - Novartis
Sirdalud MR - Novartis, Dr. Reddy's Laboratories, Euro Registratie, Medcor Pharmaceuticals
Ternelax - Wander
Ternelin - Novartis, Sandoz
Tilax - Riyadh Pharma
Tinize - Genome Pharmaceuticals
Tizacom - Combiphar
Tizafen - Akros Pharma
Tizan - Sun Pharmaceutical Industries, Pharmaland, Sin Phyu Kyun Company
Tizanidin - Actavis, Alternova, Orion Pharma, Teva
Tizanidina - Davur Laboratorios, Teva
Tizanidine - Actavis, Alphapharm, Eon Labs, Generics UK, Mylan, Sandoz, Teva
Tizanor - Orion Pharma
Tizpa - Blue Cross Laboratories, Gold Cross, S.J. & G. Fazul Ellahie
Zanaflex - Acorda Therapeutics, Cephalon, Elan Pharmaceuticals, Paladin Laboratories, Shire, Squire Pharmaceuticals, Zeneus Pharma
Other medicines used in combinations with tizanidine:
Aceclofenac
Acetaminophen
Ciprofloxacin
Diclofenac
Ibuprofen
Mefenamic Acid
Nimesulide
Serrapeptase
Valdecoxib
References and external sources:
Tizanidine main article on Wikipedia: https://en.wikipedia.org/wiki/Tizanidine
Tizanidine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Tizanidine
Tizanidine Hydrochloride on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Tizanidine-hydrochloride
Tizanidine medicine on DrugBank: https://go.drugbank.com/drugs/DB00697
Tizanidine FAQ on MedlinePlus (revised 06/20/2024): https://medlineplus.gov/druginfo/meds/a601121.html
Zanaflex (Tizanidine Hydrochloride) capsules and tablets drug label on DailyMed (revised November 1, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Sun Pharma Tizanidine tablets drug label on DailyMed (revised October 9, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Zanaflex (Tizanidine Hydrochloride) capsules 2 mg, 4 mg, 6 mg, and tablets 4 mg for oral use official prescribing information from the U.S. FDA (revised 11/2013): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Sirdalud (Tizanidine Hydrochloride) tablets prescribing information from MIMS: https://www.mims.com/philippines/drug/info/sirdalud?type=full
Zanaflex (Tizanidine) 2 mg, 4 mg tablets package information leaflet from the Health Products Regulatory Authority (revised February 2017): https://www.hpra.ie/img/uploaded/swedocuments/...
Revised: October 2024
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