Product Name: Clotrimazole
Generic Name: Clotrimazole
Common Brands: Femcare, Gyne-Lotrimin, Lotrimin
Pharmaceutical Categories: Antibiotics, Anti-Infectives
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Here is an additional general information about this medication active ingredient clotrimazole:
Clotrimazole is an antifungal agent of imidazole derivatives group for topical use. This medication has an effect at the expense of the synthesis of ergosterol, which is part of the cell membrane of fungi. Clotrimazole has a broad spectrum of action.
Clotrimazole is active against dermatophytes, molds, fungi of the genus Candida, Malassezia furfur.
This drug is also active against Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas vaginalis.
For external use clotrimazole is well into the various layers of the skin reaching therapeutic concentrations. When this medication applied topically a small amount of it absorbed into the bloodstream.
Why is Clotrimazole prescribed?
Fungal skin and mucous membranes: ringworm, tinea, trichophytosis, athlete, mikrosporiya, candidiasis, a fungal interdigital erosion, fungal paronychia; fungal infections complicated by a secondary pyoderma; colorful lichen, erythrasma; thrush; Candida vulvitis, vulvovaginitis, balanitis, trichomoniasis; for the renovation of the birth canal before delivery.
Dosage and administration
When Clotrimazole used externally it applied to affected skin 2-3 times / day in 2-4 weeks.
For local orally this medicine used 1-2 times / day, no more than 7 days.
Intravaginal - on 100-500 mg for 1-6 days.
Clotrimazole side effects, adverse reactions
Local reactions: contact allergic dermatitis, redness, burning sensation.
When applied topically to the skin: erythema, blisters, swelling, burning and tingling, irritation and flaking skin.
When applied topically for the treatment of urogenital infections: itching, burning, redness and swelling of the mucous membrane, vaginal discharge, frequent urination, intercurrent cystitis, burning sensation in the penis with a partner, pain during sexual intercourse.
When applied topically in the oral cavity: redness of the oral mucosa, burning sensation and tingling at the site of application, irritation.
Hypersensitivity to clotrimazole, I trimester of pregnancy.
Using during pregnancy and breastfeeding
In experimental studies there have been found that clotrimazole used in high doses exerts embryotoxic effect.
It is not known whether Clotrimazole released in breast milk. Although clotrimazole is not contraindicated during pregnancy and lactation, it should be considered a potential risk when selecting antifungal therapy.
Prescribed intravaginal Dosage forms of Clotrimazole is not used during menstruation.
To prevent reinfection it should be simultaneous treatment of sexual partners.
Clotrimazole is not recommended for use in ophthalmology.
Clotrimazole drug interactions
Simultaneous administration of Clotrimazole with amphotericin B, nystatin, natamycin activity of clotrimazole decreases.
Clotrimazole in case of emergency / overdose
Symptoms: anorexia, nausea, vomiting, stomachodynia, abnormal liver function, rarely - drowsiness, hallucinations, thamuria, allergic skin reactions.
Treatment: taking activated charcoal, symptomatic therapy.