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Product Name: Metronidazole
Generic Name: Metronidazole
Common Brands: Flagyl
Pharmaceutical Categories: Antibiotics, Anti-Infectives, Antiparasitic
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Metronidazole (trade names include Flagyl, Amrizole, Anaerobex, Anaerobyl, Apo-Metronidazole, Arilin, Aristogyl, Bemetrazole, Dazomet, Dumozol, Elyzol, Flagyl-ER, Flazol, Klion, Metazol, MetroCream, Metroderme, MetroGel, Metrogyl, Metrolag, Metronidazol Normon, Metronide, Metrosa, Metrozine, NidaGel, Noritate, Nuvessa, PMS-Metronidazole, Protogyl, Riazole, Rosadan, Rosiced, Rozex, Supplin, Topmetro, Trichazole, Trichopol, Trichozole, Vagimid, Vandazole, Zidoval) is an anti infective and antiprotozoal medication for topical and systemic use from imidazole derivatives pharmacological group. This medicine is indicated for the treatment of susceptible anaerobic bacterial and protozoal infections like respiratory tract, reproductive system, vaginal diseases, gastrointestinal tract, intraabdominal, skin and soft tissue, bone, joint infections. Flagyl is effective for the therapy of pelvic inflammatory disease, endocarditis, bacterial vaginosis (bacterial vaginitis), bacteremia, dracunculiasis (dracunculus), giardiasis, trichomoniasis, dientamoeba fragilis, diverticulitis, meningitis, nongonococcal urethritis, peritonitis, pouchitis, pseudomembranous colitis, amebiasis, pneumonia, aspiration pneumonia, lung abscess, Crohn's disease, Lemierre's syndrome, deep neck infections, periodontal disease, dental abscess, tooth infections, perioral dermatitis, rosacea, fungating wounds, Clostridium difficile colitis, liver abscesses, pleuropulmonary infections, brain abscesses, other infections caused by Bacteroides, Balantidium coli, Clostridium, Dracunculus medinensis, Entamoeba histolytica, Fusobacterium, Helicobacter Pylori, Peptostreptococcus, Prevotella, Trichomonas vaginalis; in women to prevent preterm birth associated with risk factors such as bacterial vaginosis; for surgical prophylaxis, prophylaxis of sexually transmissible diseases; as hypoxic radiosensitizer against hypoxic tumors. Metronidazole is also widely used in veterinary to treat some infections of dogs, cats, fish, other companion pets and animals. It works by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria.
Customers also buy these medications from the same pharmacological classes:
Amphotericin B (Abelcet)
Azanidazole (Triclose)
Betamethasone, Clotrimazole (Lotrisone)
Bifonazole (Canesten Once Daily)
Butoconazole (Gynazole)
Chlorhexidine (Betasept, Corsodyl)
Clotrimazole (Canesten, Gyne-Lotrimin)
Eberconazole (Ebernet)
Econazole (Spectazole)
Fenticonazole (Lomexin)
Fluconazole (Diflucan)
Flutrimazole (Micetal)
Griseofulvin (Grifulvin)
Hexetidine (Hexoral)
Isoconazole (Travogen)
Itraconazole (Sporanox)
Ivermectin (Stromectol)
Ketoconazole (Nizoral)
Miconazole (Monistat)
Natamycin (Natacyn)
Nystatin (Mycostatin)
Ornidazole (Tiberal)
Oxiconazole (Oxistat)
Posaconazole (Noxafil)
Sertaconazole (Ertaczo, Dermofix, Zalain)
Sulconazole (Exelderm)
Terbinafine (Lamisil)
Tetracycline (Sumycin)
Tioconazole (Gyno-Trosyd, Trosyd)
Voriconazole (Vfend)
Pharmaceutical and medical classifications:
5-Nitroimidazole derivatives
Amebicides
Anti infective medications
Antiamoebics
Antibacterials
Antibiotics
Antiprotozoal agents
Antiseptic skin cleansers
Local anti-infectives
Preparations for vaginal conditions
Topical chemotherapeutics used in the treatment of dermatological diseases
Veterinary, pet meds
Women's health products
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
A - Alimentary tract and metabolism
A01 - Stomatological preparations
A01A - Stomatological preparations
A01AB - Antiinfectives and antiseptics for local oral treatment
A01AB17 - Metronidazole
D - Dermatologicals
D06 - Antibiotics and chemotherapeutics for dermatological use
D06B - Chemotherapeutics for topical use
D06BX - Other chemotherapeutics
D06BX01 - Metronidazole
G - Genito urinary system and sex hormones
G01 - Gynecological antiinfectives and antiseptics
G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids
G01AF - Imidazole derivatives
G01AF01 - Metronidazole
J - Antiinfectives for systemic use
J01 - Antibacterials for systemic use
J01X - Other antibacterials
J01XD - Imidazole derivatives
J01XD01 - Metronidazole
P - Antiparasitic products, insecticides and repellents
P01 - Antiprotozoals
P01A - Agents against amoebiasis and other protozoal diseases
P01AB - Nitroimidazole derivatives
P01AB01 - Metronidazole
Medical conditions for metronidazole in the International Statistical Classification of Diseases and Related Health Problems:
Other bacterial intestinal infections - A04
Enterocolitis due to Clostridium difficile - A04.7
Amebiasis - A06
Other protozoal intestinal diseases - A07
Balantidiasis - A07.0
Giardiasis [lambliasis] - A07.1
Other specified protozoal intestinal diseases - A07.8
Streptococcal septicaemia - A40
Other septicaemia - A41
Other bacterial diseases, not elsewhere classified - A48
Infections with a predominantly sexual mode of transmission - A50-A64
Trichomoniasis - A59
Other spirochaetal infections - A69
Candidiasis - B37
Dracunculiasis - B72
Other bacterial agents as the cause of diseases classified elsewhere - B96
Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere - B96.81
Mental and behavioural disorders due to use of alcohol - F10
Bacterial meningitis, not elsewhere classified - G00
Intracranial and intraspinal abscess and granuloma - G06
Acute and subacute endocarditis - I33
Phlebitis and thrombophlebitis - I80
Phlebitis and thrombophlebitis of other sites - I80.8
Diseases of the respiratory system - J00-J99
Intracranial and intraspinal abscess and granuloma - G06
Bacterial pneumonia, not elsewhere classified - J15
Abscess of lung and mediastinum - J85
Pyothorax - J86
Diseases of the digestive system - K00-K95
Diseases of pulp and periapical tissues - K04
Gingivitis and periodontal diseases - K05
Stomatitis and related lesions - K12
Gastric ulcer - K25
Duodenal ulcer - K26
Crohn's disease [regional enteritis] - K50
Diverticular disease of intestine - K57
Peritonitis - K65
Other inflammatory liver diseases - K75
Abscess of liver - K75.0
Postprocedural disorders of digestive system, not elsewhere classified - K91
Pouchitis - K91.850
Infections of the skin and subcutaneous tissue - L00-L08
Impetigo - L01
Cutaneous abscess, furuncle and carbuncle - L02
Cellulitis - L03
Other local infections of skin and subcutaneous tissue - L08
Local infection of the skin and subcutaneous tissue, unspecified - L08.9
Rosacea - L71
Perioral dermatitis - L71.0
Diseases of the musculoskeletal system and connective tissue - M00-M99
Pyogenic arthritis - M00
Direct infections of joint in infectious and parasitic diseases classified elsewhere - M01
Osteomyelitis - M86
Diseases of the genitourinary system - N00-N99
Urethritis and urethral syndrome - N34
Nonspecific urethritis - N34.1
Inflammatory diseases of female pelvic organs - N70-N77
Salpingitis and oophoritis - N70
Inflammatory disease of uterus, except cervix - N71
Inflammatory disease of cervix uteri - N72
Other female pelvic inflammatory diseases - N73
Other inflammation of vagina and vulva - N76
Acute vaginitis - N76.0
Subacute and chronic vaginitis - N76.1
Preterm labor - O60
Findings of drugs and other substances, not normally found in blood - R78
Bacteremia - R78.81
Open wound of ankle, foot and toes - S91
Need for other prophylactic measures - Z29
Encounter for prophylactic surgery - Z40
Other medical care - Z51
Pregnancy category:
B2 - Australia
B - United States (No evidence of risk in humans)
Forms of active pharmaceutical ingredients (APIs):
Metronidazole Base
Metronidazole Benzoate
Metronidazole Hydrochloride
Metronidazole Hydrogen Succinate
Metronidazole Sodium
Chemical, international, and other names of this drug:
1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(Beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1H-Imidazole-1-ethanol, 2-methyl-5-nitro-
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-Methyl-5-Nitro-1H-Imidazol-1-yl)Ethanol
2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole
Benzoilmetronidazol
Benzoil Metronidazol
Benzoylmetronidazole
Imidazole-1-Ethanol, 2-Methyl-5-Nitro-
Methronidazole
Metronidasole
Metronidatsoli
Metronidazol
Metronidazolbenzoat
Metronidazole Benzoyl
Metronidazole HCl
Metronidazoli Benzoas
Metronidazolo
Metronidazols
Metronidazolum
MNZ
Most known trade names (brands and generics) worldwide:
Acuzole - Apotex, Pharmascript Pharmaceuticals
Adco-Metronidazole - Adcock Ingram, Al Pharm
Amrizole - Amriya Pharmaceutical Industries
Anaerobex - Gerot Pharmazeutika, G.L. Pharma
Anaerobyl - Pfizer
Anazol - Jazeera Pharmaceutical Industries
Apo-Metronidazole - Apotex, Nhan Tam, Pharmaforte
Arilin - Dr. August Wolff Arzneimittel, Alcina, Medika, Teva
Arilin Rapid - Dr. August Wolff Arzneimittel, Remedia, Solpharm
Aristogyl - Aristo Pharmaceuticals
Bemetrazole - Be-Tabs Pharmaceuticals
Benzoilmetronidazol - EMS Industria Farmaceutica, Sanofi
Colpofilin - Dr. Lazar Laboratorio
Dazomet - Westmont Pharmaceuticals
Deflamon - Bieffe Medital, Societa Prodotti Antibiotici
Dumozol - Alpharma, Actavis, Aurovitas, Team Medica
Efloran - KRKA
Elyzol - Alpharma, C.T.S. Chemical Industries, Cabon-Denit, Chemomedica Medizintechnik und Arzneimittel, Colgate-Palmolive, Dumex, Minapharm Pharmaceuticals, Primal Chemical, Sime Darby Marketing, Stada
Entizol - Polpharma, Nam Sinh, Polfa Tarchomin
Epaq - 3M, More Pharma Corporation
Fish Zole Forte - Thomas Laboratories
Flagenase - Liomont Laboratorios
Flagyl - Pfizer, Sanofi, Searle
Flagyl Forte - Pfizer, Sanofi
Flagyl-ER - Pfizer, Sanofi
Flagyl-S - Pfizer, Four Star, IDS Group, Primecrown, Sanofi, Unither Liquid Manufacturing
Flagyl-V - Pfizer, Sanofi
Flazol - Tabuk Pharmaceuticals, Bosch Pharmaceuticals, The Nile Company for Pharmaceuticals & Chemical Industries
Geloderm - SMB Farma Laboratorios
Ginkan - Baliarda Laboratorios
Grinazole - Septodont
Klion - Gedeon Richter, Medline, Pharmamagist
Lamblit - Novag Infancia
Medazol - Belupo
Metazol - Alliance Pharmaceuticals, Shalina Laboratories
MetroCream - Galderma
MetroCreme - Galderma
Metroderme - Galderma
MetroGel - Galderma, 3M, Derma UK, Dow Pharmaceutical Sciences, iNova Pharmaceuticals, More Pharma Corporation
Metrogyl - Unique Pharmaceutical Laboratories
Metrolag - Lagap Pharmaceuticals, Chalhoub Pharmaceuticals
Metrolet - Harsen
MetroLotion - Galderma
Metronidazol - Arena Group, Aristo Pharmaceuticals, B. Braun, Drossapharm, Genfar Laboratorios, Hexal, Jelfa Pharmaceuticals Works, Normon Laboratorios, Nycomed, Polpharma, Sandoz, Stada
Metronidazole - Actavis, Baxter, Fresenius, Generics UK, Nycomed, Pliva, Sandoz, Teva
Metronidazol-MK - MK Medicamentos, Tecnoquimicas
Metronidazolo - B. Braun, Fulton Medicinali
Metronidazolo Same - Savoma Medicinali
Metronide - Sanofi, Clonmel Healthcare, Prodotti Laboratorio Farmaceutico
Metropast - Pasteur Laboratorios
Metroruboril - Isis Pharmaceuticals
Metrosa - Dr. August Wolff Arzneimittel, Linderma, Remedia
Metrovax - Vivax Pharmaceuticals
Metrozine - Pfizer, Monsanto Far East, Searle Pakistan
Metrozol - Arrow Pharma, Bosnalijek
Negazole - Julphar Gulf Pharmaceutical Industries
NidaGel - 3M, Graceway Pharmaceuticals, Medicis Pharmaceutical Corporation, Valeant Pharmaceuticals
Nidagyl - Star Laboratories
Noritate - Sanofi, Dermik Laboratories, Ebewe Pharma, Finn Vita Laboratorio, Ingens Laboratorios, Medibrands, Valeant Pharmaceuticals
Norzol - P & D Pharmaceuticals, Rosemont Pharmaceuticals
Nuvessa - Allergan, Actavis
Orvagil - Galenika
Otrozol - Comerciosa, Pisa Laboratorios
Ovufem - Bernabo Laboratorios
Perilox - Drossapharm
PMS-Metronidazole - Pharmascience
Promuba - Meprofarm
Protogyl - Xepa-Soul Pattinson, Apex Pharma Marketing, Grafton Pharmasia, Harmann Pharmaceutical Laboratories, Simed Laboratoires, Societe Arabe des Industries Pharmaceutiques, Tack Fung Medical Supplies
Riazole - Riyadh Pharma
Rosadan - Medimetriks Pharmaceuticals
Rosiced - Pierre Fabre
Rozex - Galderma
Supplin - Novartis, Biochemie, Sandoz
Topmetro - Tetramed Biotek
Trichazole - Aspen, Pharmacare
Trichopol - Polpharma, Akrikhin, Polfa Warszawa
Trichozole - Sanofi, Mylan, Pacific Pharmaceuticals, Spencer Pharma
Tricofin - Raymos Laboratorios
Vagilen - Alfa Wassermann, Farmigea, Opalia Pharma Laboratories
Vagimid - Apogepha Arzneimittel
Vagizol - Kimia Farma
Vandazole - Teva, Upsher-Smith Laboratories
Zidoval - 3M, B & S Healthcare, iNova Pharmaceuticals, Meda, Metropolis Healthcare
Other medicines used in combinations with metronidazole:
Acetylspiramycin
Amoxicillin
Benzalkonium Chloride
Bismuth Subcitrate
Cefuroxime
Ciprofloxacin
Clarithromycin
Clotrimazole
Dexamethasone
Diiodohydroxyquinoline
Diloxanide Furoate
Furazolidone
Ivermectin
Lansoprazole
Miconazole
Neomycin
Norfloxacin
Nystatin
Omeprazole
Pantoprazole
Povidone-Iodine
Rabeprazole
Spiramycin
Tetracycline
Vonoprazan
References and external sources:
Metronidazole main article on Wikipedia: https://en.wikipedia.org/wiki/Metronidazole
Metronidazole compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Metronidazole
Metronidazole medicine on DrugBank: https://go.drugbank.com/drugs/DB00916
Metronidazole FAQ on MedlinePlus (revised 12/15/2023): https://medlineplus.gov/druginfo/meds/a689011.html
Metronidazole Topical FAQ on MedlinePlus (revised 12/15/2017): https://medlineplus.gov/druginfo/meds/a682244.html
Flagyl (Metronidazole) film-coated tablets drug label on DailyMed (revised October 30, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Flagyl (Metronidazole) capsules drug label on DailyMed (revised October 20, 2023): https://dailymed.nlm.nih.gov/dailymed/lookup...
Innogenix Metronidazole tablets drug label on DailyMed (revised September 22, 2022): https://dailymed.nlm.nih.gov/dailymed/lookup...
Flagyl (Metronidazole) 250 mg tablets official prescribing information from the U.S. FDA (revised 12/2021): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Flagyl (Metronidazole) tablets prescribing information from Pfizer, Inc. (revised 10/2023): https://labeling.pfizer.com/showlabeling.aspx?id=570
Flagyl (Metronidazole) product information from Pfizer pharmaceutical company: https://www.pfizer.com/products/product-detail/flagyl
Flagyl (Metronidazole) 200 mg, 400 mg tablets consumer medicine information from NPS MedicineWise (revised March 2022): https://www.nps.org.au/assets/medicines/...
Flagyl (Metronidazole) 400 mg tablets package information leaflet for users on Medicines.org.uk (revised June 2023): https://www.medicines.org.uk/emc/files/pil.9238.pdf
Revised: June 2024
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