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Product Name: Cyproheptadine
Generic Name: Cyproheptadine
Common Brands: Periactin
Pharmaceutical Categories: Anti-Allergic, Asthma
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Cyproheptadine (trade names include Periactin, Cipla-Actin, Ciplactin, Peritol, Practin, Pronicy, Viternum) is a first-generation antihistamine medication from antihistamines for systemic use pharmacological group. This medicine is prescribed for the therapy of hay fever, allergic rhinitis, other allergic reactions; as a preventive treatment against migraine, cluster headaches. It is also used off-label in the treatment of Cushing's syndrome, cyclical vomiting syndrome in infants, to improve akathisia in people on antipsychotic medications, to treat various dermatological conditions, including pruritus, urticaria, psychogenic itch, drug-induced hyperhidrosis (excessive sweating); prevention of blister formation for some people with epidermolysis bullosa simplex; to increase appetite and weight gain in people with anorexia, anorexia nervosa, cystic fibrosis, in children who are wasting or with failure to thrive; in the management of moderate to severe cases of serotonin syndrome, SSRI induced sexual dysfunction.
Cyproheptadine is also indicated in veterinary for cats as an appetite stimulant and as an adjunct in the treatment of asthma; as a second line treatment for pituitary pars intermedia dysfunction in horses.
It works as very potent antihistamine or inverse agonist of the H1 receptors.
Customers also buy these medications from the same pharmacological classes:
Albuterol (Salbutamol)
Azelastine (Astelin)
Cetirizine (Zyrtec)
Desloratadine (Clarinex)
Dexamethasone (Dexone)
Diphenhydramine (Benadryl)
Fexofenadine (Allegra)
Hydroxyzine (Atarax)
Ketotifen (Zaditor)
Loratadine (Claritin)
Meclizine (Antivert)
Mizolastine (Mizollen)
Mometasone (Elocon, Nasonex)
Montelukast (Singulair)
Olopatadine (Patanol)
Promethazine (Phenergan)
Triamcinolone (Aristocort)
Pharmaceutical and medical classifications:
Anti allergic drugs
Anticholinergic medications
Antihistamine pills
Appetite stimulants
First-generation antihistamines
H1-antihistaminics
Histamine H1-receptor antagonists
Local anesthetics
Serotonin receptor antagonists
Veterinary medications, pet meds
Weight gain pills
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
R - Respiratory system
R06 - Antihistamines for systemic use
R06A - Antihistamines for systemic use
R06AX - Other antihistamines for systemic use
R06AX02 - Cyproheptadine
Medical conditions for cyproheptadine in the International Statistical Classification of Diseases and Related Health Problems:
Cushing's syndrome - E24
Cystic fibrosis - E84
Eating disorders - F50
Anorexia nervosa, unspecified - F50.00
Other extrapyramidal and movement disorders - G25
Drug induced akathisia - G25.71
Migraine - G43
Other headache syndromes - G44
Vasomotor and allergic rhinitis - J30
Allergic rhinitis due to pollen - J30.1
Pruritus - L29
Pruritus scroti - L29.1
Eccrine sweat disorders - L74
Primary focal hyperhidrosis, axilla - L74.510
Other disorders of the skin and subcutaneous tissue - L80-L99
Male erectile dysfunction - N52
Drug-induced erectile dysfunction - N52.2
Epidermolysis bullosa - Q81
Epidermolysis bullosa simplex - Q81.0
Nausea and vomiting - R11
Lack of expected normal physiological development in childhood and adults - R62
Adult failure to thrive - R62.7
Symptoms and signs concerning food and fluid intake - R63
Anorexia - R63.0
Superficial injury of knee and lower leg - S80
Blister (nonthermal), right lower leg, initial encounter - S80.821A
Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified - T43
Pregnancy category:
A - Australia
B - United States (No evidence of risk in humans)
Forms of active pharmaceutical ingredients (APIs):
Cyproheptadine Base
Cyproheptadine Acefyllinate
Cyproheptadine Anhydrous
Cyproheptadine Epoxide
Cyproheptadine Glucuronide
Cyproheptadine Hydrochloride
Cyproheptadine Hydrochloride Anhydrous
Cyproheptadine Hydrochloride Hydrate
Cyproheptadine Hydrochloride Monohydrate
Cyproheptadine Hydrochloride Sesquihydrate
Cyproheptadine N-Oxide
Cyproheptadine Pyridoxal Phosphate
Cyproheptadine Orotate
Chemical, international, and other names of this drug:
4-(5H-dibenzo[a-e]cycloheptatrienylidene)-1-metylpiperidine
Chlorhydrate de Cyproheptadine
Cipro-Heptadina
Ciproeptadina
Ciproheptadin
Ciproheptadina
Cyproheptadin
Cyproheptadine HCl
Cyproheptadinhydrochlorid
Cyproheptadini Hydrochloridum
Cyproheptadinum
Cyproheptadyna
Most known trade names (brands and generics) worldwide:
Cipla-Actin - Cipla
Ciplactin - Cipla, LBS Laboratory
Periactin - Merck, Avantgarde, B L Hua, Johnson & Johnson, M & H Manufacturing, Sigma-Tau Pharmaceuticals
Periactine - Merck, Teofarma
Peritol - Egis, Medphano Arzneimittel, Themis Medicare
PMS-Cyproheptadine - Pharmascience
Practin - Wockhardt
Pronicy - Kalbe Farma
Viternum - Labomed Instituto Farmaceutico, Juste Quimico-Farmaceutica, OM Pharma, Senosiain Laboratorios
Other medicines used in combinations with cyproheptadine::
Amino Acids
Arginine
Carnitine
Clonixin
Deanol Aceglumate
Dexamethasone
Ergotamine Tartrate
Fosforylethanolamine
Ginkgo Biloba
Hematoporphyrin
Lysine
Metoclopramide
Minerals
Pantethine
Pepsin
Peptone
Pyritinol
Sorbitol
Tricholine Citrate
Vitamins
References and external sources:
Cyproheptadine main article on Wikipedia: https://en.wikipedia.org/wiki/Cyproheptadine
Cyproheptadine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/cyproheptadine
Cyproheptadine Hydrochloride compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Cyproheptadine-hydrochloride
Cyproheptadine medicine on DrugBank: https://go.drugbank.com/drugs/DB00434
Cyproheptadine Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000625
Cyproheptadine FAQ on MedlinePlus (revised 02/15/2018): https://medlineplus.gov/druginfo/meds/a682541.html
Cyproheptadine overdose information on MedlinePlus (revised 07/01/2023): https://medlineplus.gov/ency/article/002617.htm
Quagen Cyproheptadine tablets drug label on DailyMed (revised March 8, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Amneal Cyproheptadine tablets drug label on DailyMed (revised December 30, 2023): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Teva Cyproheptadine Hydrochloride tablets USP 4 mg for oral use official prescribing information from the U.S. FDA: https://www.accessdata.fda.gov/drugsatfda_docs/label...
Periactin (Cyproheptadine Hydrochloride) 4 mg tablets product information from GP2U TeleHealth (revised 17 November 2011): https://gp2u.com.au/static/pdf/P/PERIACTIN-PI.pdf
Periactin (Cyproheptadine Hydrochloride Sesquihydrate) 4 mg tablets consumer medicine information from NPS MedicineWise (revised November 2021): https://www.nps.org.au/medicine-finder/periactin-tablets
Periactin (Cyproheptadine Hydrochloride) 4 mg tablets package information leaflet for users from Medicines.org.au (revised October 2007): https://apps.medicines.org.au/files/mkcperia.pdf
Revised: March 2024
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