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Product Name: Hydroxyzine
Generic Name: Hydroxyzine
Common Brands: Atarax, Vistaril, Ucerax
Pharmaceutical Categories: Anti-Allergic, Asthma
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Hydroxyzine (trade names include Atarax, Iterax, Ataraxone, Bestalin, Hixizine, Hizin, Teva-Hydroxyzine, Ucerax, Vistaril) is an antihistamine and anti-anxiety medication from diphenylmethane derivatives pharmacological group. This medicine is used to treat anxiety, insomnia, tension, psychoneurosis, neurological disorders, interstitial cystitis; for sedation before and after general anesthesia; for therapy of itching and irritations due to certain allergies and allergic conditions, including hives, urticaria, atopic or contact dermatitis, histamine-mediated pruritus; as an antiemetic for the reduction of nausea and vomiting, including that due to motion sickness; with other medicines to induce sleep before surgery; as a weak analgesic to relieve pain; to relieve the effects of opioid withdrawal; experimentally for the treatment of COVID-19 to degree of direct antiviral effect; and for other medical purposes. It works as a selective histamine H1 receptor inverse agonist. This mechanism of action is responsible for its antihistamine and sedative effects.
Customers also buy these medications from the same pharmacological classes:
Brallobarbital, Hydroxyzine, Secobarbital (Vesparax)
Buspirone (Buspar)
Captodiame (Covatine)
Cetirizine (Zyrtec)
Cyclopentolate (Cyclogyl)
Cyproheptadine (Periactin)
Danazol (Danocrine)
Desloratadine (Clarinex)
Dexamethasone (Dexone)
Dipyridamole (Persantine)
Doxepin (Sinequan)
Duloxetine (Cymbalta)
Ephedrine, Hydroxyzine, Theophylline (Marax)
Escitalopram (Lexapro)
Fexofenadine (Allegra)
Fluvoxamine (Luvox)
Imipramine (Tofranil)
Mycophenolate Mofetil (Cellcept)
Nortriptyline (Aventyl, Pamelor)
Phenytoin (Dilantin)
Promethazine (Phenergan)
Selegiline (Eldepryl)
Tacrolimus (Prograf)
Tranexamic Acid (Cyklokapron)
Trazodone (Desyrel)
Venlafaxine (Effexor)
Pharmaceutical and medical classifications:
Analgesics
Anti allergic drugs
Anti anxiety medications
Anti obsessive agents
Antihistamines
Antipsychotics
Anxiolytics
COVID-19 products
Hypnotics and sedatives
Meds for opioid withdrawal
Pain relief medicines
Piperazine derivatives
Premedication before surgery
Selective histamine H1 receptor agonists
Sleep aid tablets
Tranquilizers
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N05 - Psycholeptics
N05B - Anxiolytics
N05BB - Diphenylmethane derivatives
N05BB01 - Hydroxyzine
Medical conditions for hydroxyzine in the International Statistical Classification of Diseases and Related Health Problems:
Opioid related disorders - F11
Anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders - F40-F48
Generalized anxiety disorder - F41.1
Other nonpsychotic mental disorders - F48
Other headache syndromes - G44
Sleep disorders - G47
Insomnia - G47.0
Other disorders of nervous system not elsewhere classified - G98
Dermatitis and eczema - L20-L30
Atopic dermatitis - L20
Allergic contact dermatitis - L23
Irritant contact dermatitis - L24
Unspecified contact dermatitis - L25
Pruritus - L29
Urticaria - L50
Cystitis - N30
Interstitial cystitis (chronic) - N30.1
Nausea and vomiting - R11
Nausea - R11.0
Vomiting - R11.1
Pain, unspecified - R52
Other and unspecified effects of other external causes - T75
Motion sickness - T75.3
Adverse effects, not elsewhere classified - T78
Allergy, unspecified - T78.40
Other complications of surgical and medical care, not elsewhere classified - T80-T88
COVID-19 - U07.1
Other medical care - Z51
Pregnancy category:
A - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Hydroxyzine Base
Hydroxyzine Dihydrochloride
Hydroxyzine Embonate
Hydroxyzine Hydrochloride
Hydroxyzine Pamoate
Chemical, international, and other names of this drug:
1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine
Chlorhydrate d'Hydroxyzine
Cloridrato de Hidroxizina
Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
Hidroksisien
Hidroksizin
Hidroxicina
Hidroxizina Clorhidrato
Hidroxizina
Hydroksitsiini
Hydroksitsiinihydrokloridi
Hydroksyzinhydroklorid
Hydroksyzyna
Hydroksyzyny
Hydroxine
Hydroxizin
Hydroxizine
Hydroxizinhydroklorid
Hydroxizinum
Hydroxycine
Hydroxyzin
Hydroxyzina
Hydroxyzindihydrochlorid
Hydroxyzine DiHCl
Hydroxyzine HCl
Hydroxyzinembonat
Hydroxyzinhydrochlorid
Hydroxyzini Hydrochloridum
Hydroxyzinum
Hydroxyzyne
Idrossizina
Idroxizina
N-(4-Chlorobenzhydryl)-N'-(hydroxyethyloxyethyl)piperazine
Most known trade names (brands and generics) worldwide:
Bestalin - Lapi
Iterax - UCB Pharma, GlaxoSmithKline
Apo-Hydroxyzine - Apotex
Atarax - Pfizer, Dr. Reddy's Laboratories, GlaxoSmithKline, NextPharma, Pliva, UCB Pharma
Ataraxone - Dr. Lazar Laboratorio
Dalun - Medipharm
Dormirax - Burapha Dispensary
Fasarax - Prater Laboratorio
Hiderax - Franco Colombiano Laboratorio
Hidroxicina - American Generics, Genfar Laboratorios, Ryan Laboratorios
Hidroxina - ICN Pharmaceuticals
Histan - Siam Pharmaceutical
Hixizine - Theraskin
Hizin - Ranbaxy, Daiichi Sankyo, Unichem Laboratories
Hozen - Biochemix Health Care
Hydil - Psychotropics India
Hydrox - T Man Pharma
Hydroxyzine - Alpharma, IVAX, Mylan, Pliva, Pro Doc, Sandoz, Sun Pharmaceutical Industries, Wyeth
Hydroxyzinum-VP - PharmaSwiss
HY-Pam - Teva
Hyzine - Hyrex Pharmaceuticals, Utopian
Navicalm - UCB Pharma
Nexit - Grunenthal
Novo-Hydroxyzin - Novopharm
Otarex - Teva
PMS-Hydroxyzine - Pharmascience
Prugo - Cosme Health Care
Taraxin - T.O. Chemicals
Teva-Hydroxyzine - Teva
Ucerax - UCB Pharma
Vistaril - Pfizer
Xyzine - Nakornpatana Pharm
Other medicines used in combinations with hydroxyzine:
Brallobarbital
Buclizine
Carnitine
Chlorphenamine
Codeine
Ephedrine
Ergoloid Mesylates
Ethaverine
Dyphylline
Hyoscyamine
Inositol Nicotinate
Meclizine
Multivitamins
Oxyphencyclimine
Pentaerithrityl Tetranitrate
Prednisolone
Propranolol
Propyphenazone
Secobarbital
Theobromine
Theophylline
Vitamin B3 (Nicotinic Acid)
References and external sources:
Hydroxyzine main article on Wikipedia: https://en.wikipedia.org/wiki/Hydroxyzine
Hydroxyzine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyzine
Hydroxyzine HCl on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyzine-Hcl
Hydroxyzine medicine on DrugBank: https://go.drugbank.com/drugs/DB00557
Hydroxyzine Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000343
Hydroxyzine FAQ on MedlinePlus (revised 02/15/2017): https://medlineplus.gov/druginfo/meds/a682866.html
Hydroxyzine overdose on MedlinePlus (revised 11/13/2021): https://medlineplus.gov/ency/article/002654.htm
Atarax (Hydroxyzine Hydrochloride) tablets and syrup drug label on DailyMed (revised June 20, 2006): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Northstar Rx Hydroxyzine Hydrochloride tablets drug label on DailyMed (revised December 6, 2022): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Teva Hydroxyzine Hydrochloride tablets drug label on DailyMed (revised October 31, 2016): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Vistaril (Hydroxyzine Pamoate) capsules drug label on DailyMed (revised November 29, 2022): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Sandoz Hydroxyzine Pamoate capsules drug label on DailyMed (revised November 30, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Atarax (Hydroxyzine Hydrochloride) 10 mg, 25 mg film-coated tablets and 2 mg/ml syrup prescribing information from GlaxoSmithKline pharmaceutical company (revised 26 June 2019): https://gskpro.com/content/dam/global/...
Vistaril (Hydroxyzine Pamoate) capsules and oral suspension official prescribing information from the U.S. FDA (revised May 2014): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Vistaril (Hydroxyzine Pamoate) product information from Pfizer pharmaceutical company: https://www.pfizermedicalinformation.com/en-us/vistaril
Vistaril (Hydroxyzine Pamoate) capsules and oral suspension prescribing information from Pfizer (revised September 2019): https://labeling.pfizer.com/ShowLabeling.aspx?format=PDF&id=672
Atarax (Hydroxyzine Hydrochloride) medication guide from RxList (revised 07/30/2020): https://www.rxlist.com/atarax-drug.htm
Ucerax (Hydroxyzine Hydrochloride) 25 mg film-coated tablets patient information leaflet from The Health Products Regulatory Authority (revised 12/2021): https://www.hpra.ie/img/uploaded/...
Revised: January 2023
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