Product Name: Tolvaptan
Generic Name: Tolvaptan
Common Brands: Samsca
Pharmaceutical Categories: Aquaretic drugs
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Tolvaptan (trade names include Samsca, Jinarc, Jynarque, Natrise, Resodim, Tolvat, Vaptan) is an aquaretic drug, diuretic medication from vasopressin antagonists pharmacological group. This medicine is used for the treatment of low blood sodium levels (hyponatremia) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). It works as a selective, competitive vasopressin receptor 2 (V2) antagonist.
Customers also buy these medications from the same pharmacological classes:
Amiloride, Furosemide (Frumil)
Pharmaceutical and medical classifications:
Vasopressin V2-receptor antagonist
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
C - Cardiovascular system
C03 - Diuretics
C03X - Other diuretics
C03XA - Vasopressin antagonists
C03XA01 - Tolvaptan
Medical conditions for tolvaptan in the International Statistical Classification of Diseases and Related Health Problems:
Hyperfunction of pituitary gland - E22
Syndrome of inappropriate secretion of antidiuretic hormone - E22.2
Other disorders of fluid, electrolyte and acid-base balance - E87
Hypo-osmolality and hyponatremia - E87.1
Heart failure - I50
Fibrosis and cirrhosis of liver - K74
D - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Chemical, international, and other names of this drug:
Most known trade names (brands and generics) worldwide:
Jinarc - Otsuka Pharmaceutical
Jynarque - Otsuka Pharmaceutical
Natrise - Sun Pharmaceutical Industries
Resodim - Lupin
Samsca - Otsuka Pharmaceutical
Tenax - Edallia Pharmaceuticals
Tolaqua - Abhay Pharma
Tolsama - MSN Laboratories, Mutual Medical Agencies
Tolvaptoris - Steris Healthcare
Tolvasca - Glenmark Pharmaceuticals, Mili Health Care
Tolvat - MSN Laboratories, Shaurya Internationa
Tvaptan - Lahar Pharmaceuticals
Vaptan - Steadfast MediShield
References and external sources:
Tolvaptan main article on Wikipedia: https://en.wikipedia.org/wiki/Tolvaptan
Tolvaptan compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Tolvaptan
Tolvaptan medicine on DrugBank: https://www.drugbank.ca/drugs/DB06212
Tolvaptan for low blood sodium FAQ on MedlinePlus (revised 08/15/2018): https://medlineplus.gov/druginfo/meds/a609033.html
Tolvaptan for kidney disease FAQ on MedlinePlus (revised 06/15/2020): https://medlineplus.gov/druginfo/meds/a620041.html
Samsca (Tolvaptan) tablets drug label on DailyMed (revised June 18, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Jynarque (Tolvaptan) tablets and kit drug label on DailyMed (revised July 21, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Samsca (Tolvaptan) tablets for oral use 15 mg and 30 mg official prescribing information and medication guide from the U.S. FDA (revised 04/2021): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Samsca (Tolvaptan) tablets for oral use 15 mg and 30 mg prescribing information and medication guide from Otsuka Pharmaceutical company (revised 04/2021): https://www.otsuka-us.com/media/static/Samsca-PI.pdf
Jynarque (Tolvaptan) tablets for oral use 15 mg, 30 mg, 45 mg, 60 mg and 90 mg prescribing information and medication guide from Otsuka Pharmaceutical company (revised 10/2020): https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf
Samsca (Tolvaptan) tablets official website powered by Otsuka America Pharmaceutical, Inc.: https://www.samsca.com/
Samsca (Tolvaptan) 7.5 mg, 15 mg, 30 mg tablets package information leaflet on Medicines.org.uk (revised 09/2021): https://www.medicines.org.uk/emc/files/pil.6635.pdf
Jinarc (Tolvaptan) 15 mg, 30 mg, 45 mg, 60 mg, 90 mg tablets package information leaflet on Medicines.org.uk (revised 01/2022): https://www.medicines.org.uk/emc/files/pil.6846.pdf
Revised: May 2022
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