Compare online pharmacy prices and services

Product Name: Valacyclovir

Generic Name: Valacyclovir

Common Brands: Valtrex

Pharmaceutical Categories: Antivirals

Here is a list of pharma shops where you can buy Valacyclovir online, order cheap and qualitative Valacyclovir, purchase brand or generic Valacyclovir, compare pharmacy drug prices and cost of medications from popular and trusted online pharmacies and drugstores selling this or related pharmaceutical products:

Online Pharmacy Product
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • 5% discount coupon: 5OFF
  • Payment: Visa, MasterCard, AmEx, JCB, Bitcoin
  • Shipping: Worldwide
  • Delivery: Unregistered Mail, Trackable Courier
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • 5% discount coupon: dmeds5
  • Payment: Visa, MasterCard, Bitcoin, Ethereum
  • Shipping: Worldwide, except some EU countries
  • Delivery: International Airmail, Trackable Courier Service
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • 5% discount coupon: A1XKPKC
  • Payment: Visa, MasterCard, PayPal, Bitcoin
  • Shipping: Worldwide
  • Delivery: AirMail, Express Mail Service
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • 8% discount coupon: jaged8
  • Payment: Visa, MasterCard, eCheck / ACH, Bitcoin
  • Shipping: Worldwide
  • Delivery: Registered Shipping, Express Delivery
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • 10% discount coupon: qRr3ZyvhPv
  • Payment: Visa, MasterCard, E-Check (ACH)
  • Shipping: USA, UK, Europe, Canada, Australia, Worldwide
  • Delivery: Registered Mail, EMS International
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • 5% discount coupon: MSD5
  • Payment: Visa, MasterCard, AmEx, E-Check (ACH), Bitcoin
  • Shipping: Worldwide
  • Delivery: Regular Airmail, Express Courier
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • 10% discount coupon: hf-5478
  • Payment: Visa, MasterCard
  • Shipping: Worldwide
  • Delivery: AirMai, EMS
  • Valtrex tablets 1000 mg
  • Valtrex tablets 500 mg
  • Payment: Visa, MasterCard
  • Shipping: USA, UK, Worldwide, except EU
  • Delivery: Regular Delivery Service, Express Delivery Service

  • Here is an additional general information about this medication active ingredient valacyclovir (valaciclovir):

    Pharmacological action

    Valacyclovir is an antiviral agent of nucleosides group. Valacyclovir (valaciclovir) is the L-valine ester of acyclovir being thus a prodrug.
    After absorption into the blood valacyclovir almost completely converted to acyclovir under the influence of hepatic enzyme valacyclovir-hydrolase. In turn Acyclovir formed from valacyclovir affected by the virus penetrates cells where under the influence of the viral enzyme thymidine kinase converted into a monophosphate, then under the influence of cellular kinases - in the active diphosphate and triphosphate. Acyclovir triphosphate inhibits DNA polymerase and thus violates the replication of virus DNA. In addition the violation of the replication of viral DNA may be a result of incorporation of acyclovir into its structure. Thus the high selectivity of valacyclovir for tissues infected with a virus, because the stage I reaction chain phosphorylation mediated by the enzyme produced by the virus.
    This drug is active against Herpes Simplex virus types 1 and 2, Varicella Zoster, cytomegalovirus, Epstein-Barr virus, human herpes virus 6.


    After oral administration Valacyclovir is well absorbed from the gastrointestinal tract rapidly and almost completely converted to acyclovir and L-valine by the enzyme valacyclovir-hydrolase.
    After a single dose of 0.25-2 g of valacyclovir Cmax of acyclovir in healthy volunteers with normal renal function is an average of 10-37 mmol (2.2-8.3 mg / ml) and achieved in 1-2 hours.
    Bioavailability of acyclovir when receiving from 1 g of valaciclovir is 54% and is independent of ingestion.
    Cmax of valaciclovir in plasma is only 4% of the acyclovir and achieved an average of 30-100 minutes after ingestion, after 3 h Cmax level remains unchanged or declines.
    Binding of valaciclovir to plasma proteins is very low - 15%.

    Why is Valacyclovir prescribed?

    Valacyclovir is used for the treatment and prevention of infectious diseases caused by Herpes Zoster.
    Prevention of cytomegalovirus infection developing in organ transplantation.

    Dosage and administration

    For oral administration a single Valacyclovir dose for adults is 0.25-2 g. Frequency of admission and length of treatment depend on the evidence.
    For patients with severely impaired renal function requires correction dosing regimen.

    Valacyclovir side effects

    Digestive system: nausea, discomfort, abdominal pain, vomiting, diarrhea, anorexia; rare - transient increase of indicators of liver samples.
    CNS: headache, fatigue, dizziness, confusion, hallucinations; rare - impaired consciousness, in some cases - coma (usually in patients with impaired renal function or other predisposing factors).
    Allergic reactions: rarely - rash, urticaria, pruritus, angioedema, anaphylaxis.
    Other: rarely - thrombocytopenia, dyspnea, renal dysfunction, photosensitivity.

    Valacyclovir contraindications

    Hypersensitivity to valacyclovir (valaciclovir), acyclovir.

    Using during pregnancy and breastfeeding

    There are no adequate and well-controlled studies safety of valaciclovir in pregnancy and lactation. Prescription of Valacyclovir for this category of patients is possible in cases where the expected benefits of therapy to the mother outweighs the potential risk to the fetus or infant. It is known that acyclovir (which is a metabolite of valaciclovir) is excreted in breast milk at concentrations of 0.6-4.1 times higher than its concentration in plasma. T1/2 of acyclovir in breast milk is 2.8 h, comparable to the T1/2 from blood plasma.
    In experimental studies, valacyclovir had no teratogenic effects in rats and rabbits. For oral administration valacyclovir did not cause impaired fertility in male and female rats.

    Special instructions

    It is necessary to increase fluid intake for elderly patients during treatment.
    Patients with kidney failure have an increased risk of neurological complications while taking Valacyclovir.
    This drug used with caution in patients with liver disease.
    Clinical experience in children is missing.

    Valacyclovir drug interactions

    Clinically significant drug interactions valacyclovir with other drugs is not established.
    Acyclovir comes as unchanged in the urine through active tubular secretion. Any drugs prescribed with it at the same time and compete for the mechanism of elimination, can cause high concentrations of valaciclovir in plasma. Cimetidine and drugs that block tubular secretion in the appointment after receiving valacyclovir at a dose of 1 g of acyclovir enhance AUC rate and decrease its renal clearance.
    Simultaneous administration of acyclovir with the inactive metabolite of mycophenolate mofetil (immunosuppressant, used in transplantation) observed an increase in AUC of acyclovir and mycophenolate mofetil.
    Simultaneous administration of Valacyclovir with drugs violating renal function (including cyclosporine, tacrolimus) possibly worsening renal function.

    Valacyclovir in case of emergency / overdose

    Symptoms: sedimentation of acyclovir in renal tubules.
    Treatment: dialysis (when acute renal failure and anuria).

    Home Page | Sitemap | Privacy Policy | Cookies Policy | Terms of Service | Contact Us

    Copyright © 2007-2019