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Product Name: Amantadine
Generic Name: Amantadine
Common Brands: Amantrel, Gocovri, Symmetrel
Pharmaceutical Categories: Antivirals, Parkinson's Disease
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Amantadine (trade names include Symmetrel, Amantix, Amantrel, Gocovri, Lysovir, Mantadan, Mantadix, Osmolex ER, Parkitidin, PK-Merz, Viregyt-K) is an antiviral and antiparkinsonian drug from adamantane derivatives pharmacological group. This medication is indicated for the treatment and prophylaxis of influenza A (flu) viral infections, Parkinson's disease, parkinsonism syndromes, movement disorders, tardive dyskinesia, levodopa-induced dyskinesia in patients with Parkinson's disease, drug-induced extrapyramidal symptoms, certain side effects of some other medications. It is also used to treat multiple sclerosis related fatigue, chronic fatigue syndrome, head injury, traumatic brain injury, post-polio syndrome, autistic spectrum disorders, disorders of consciousness (such as coma, vegetative state, minimally conscious state) subarachnoid hemorrhage, cerebral hemorrhage, hypoxic encephalopathy, SSRI induced sexual dysfunction; for recreational purposes; in veterinary medicine for dogs, birds, other pets and animals. Amantadine is in research studies for the therapy of depression, attention deficit hyperactivity disorder, COVID-19. This medicine works as NMDA-type glutamate receptor antagonist by increasing dopamine release and blocking dopamine reuptake.
Related medications:
Acyclovir (Zovirax)
Amitriptyline (Elavil)
Bromocriptine (Parlodel)
Cabergoline (Dostinex)
Carbidopa, Entacapone, Levodopa (Stalevo)
Carbidopa, Levodopa (Sinemet)
Clonazepam (Klonopin, Rivotril)
Domperidone (Motilium)
Donepezil (Aricept)
Entacapone (Comtan)
Famciclovir (Famvir)
Galantamine (Reminyl)
Levodopa (Inbrija)
Memantine (Namenda)
Mirtazapine (Remeron)
Modafinil (Provigil)
Molnupiravir (Lagevrio)
Oseltamivir (Tamiflu)
Piracetam (Nootropil)
Pramipexole (Mirapex)
Procyclidine (Kemadrin)
Quetiapine (Seroquel)
Ribavirin (Copegus, Rebetol)
Rimantadine (Flumadine)
Rivastigmine (Exelon)
Ropinirole (Requip)
Selegiline (Eldepryl)
Trihexyphenidyl (Artane)
Valacyclovir (Valtrex)
Zanamivir (Relenza)
Pharmaceutical and medical classifications:
Adamantane antivirals
Anti flu products
Anti-influenzal virostatics
Antidepressants
Antiparkinson drugs
Antiparkinsonian agents
Antiviral drugs
Antivirals for systemic use
Central nervous system agents
Dopamine receptor agonists
Dopaminergic antiparkinsonism agents
Medications for the treatment of Parkinson's disease
Meds to treat ADHD
Nicotinic antagonists
NMDA receptor antagonists
Sigma-1 receptor agonists
Urological medications
Veterinary, pet meds
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N04 - Anti-parkinson drugs
N04B - Dopaminergic agents
N04BB - Adamantane derivatives
N04BB01 - Amantadine
Medical conditions for amantadine in the International Statistical Classification of Diseases and Related Health Problems (ICD):
Other psychoactive substance related disorders - F19
Other psychoactive substance use, unspecified - F19.9
Other psychoactive substance use, unspecified with other psychoactive substance-induced disorders - F19.98
Pervasive developmental disorders - F84
Autistic disorder - F84.0
Postpolio syndrome - G14
Parkinson's disease - G20
Secondary parkinsonism - G21
Dystonia - G24
Drug induced dystonia - G24.0
Dyskinesia - G24.9
Other extrapyramidal and movement disorders - G25
Extrapyramidal and movement disorders in diseases classified elsewhere - G26
Multiple sclerosis - G35
Other disorders of brain - G93
Postviral and related fatigue syndromes - G93.3
Myalgic encephalomyelitis/chronic fatigue syndrome - G93.32
Attention-deficit hyperactivity disorders - F90
Nontraumatic subarachnoid hemorrhage - I60
Nontraumatic intracerebral hemorrhage - I61
Influenza and pneumonia - J09-J18
Male erectile dysfunction - N52
Drug-induced erectile dysfunction - N52.2
Other disturbances of cerebral status of newborn - P91
Hypoxic ischemic encephalopathy [HIE] - P91.6
Sexual dysfunction, unspecified - R37
Somnolence, stupor and coma - R40
Persistent vegetative state - R40.3
Other symptoms and signs involving cognitive functions and awareness - R41
Malaise and fatigue - R53
Intracranial injury - S06
Other and unspecified injuries of head - S09
Unspecified injury of face and head - S09.9
Other complications of surgical and medical care, not elsewhere classified - T88
Unspecified adverse effect of drug or medicament - T88.7
Pregnancy category:
B3 - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Amantadine Base
Amantadine Hydrochloride
Amantadine Sulfate
Chemical, international, and other names of this drug:
1-Adamantamine
1-Adamantanamine
1-Adamantylamine
1-Adamantylazan
1-Aminoadamantane
Adamantamine
Adamantan-1-Amine
Adamantan-1-Ylamine
Adamantanamine
Adamantane,1-Amino
Adamantine
Adamantylamine
Amantadiini
Amantadin
Amantadina
Amantadine HCl
Amantadine Sulphate
Amantadinehydrochloride
Amantadinhemisulfat
Amantadinhydrochlorid
Amantadini Hydrochloridum
Amantadinsulfat
Amantadinum
Amantadyna
Amantidina
Amantidine
Aminoadamantane
Clorhidrato de Amantadina
Tricyclo(3.3.1.1(3,7))-Decan-1-Amine
Trivaline
Most known trade names (brands and generics) worldwide:
Amantadin - Hexal, Neuraxpharm Arzneimittel, Ratiopharm, Stada
Amantadine Level - ERN Laboratorios
Amantagamma - Worwag Pharma
Amantix - Merz, Grupo Farma, Natur Produkt
Amantrel - Cipla
Ammorel - Amin Pharmaceuticals
Ensorex - Alteus Biogenics
Gocovri - Adamas Pharmaceuticals, Supernus Pharmaceuticals
Infex - Merz, Marcyrl Pharmaceutical Industries
Lysovir - Alliance Pharmaceuticals
Mantadan - Boehringer Ingelheim, LXO Group
Mantadix - Bristol-Myers Squibb, DuPont, Therabel Pharma
Mantidan - Eurofarma Laboratorios, Momenta
Neomidantan - Olainfarm
Osmolex ER - Vertical Pharmaceuticals
Parkitidin - Sun Pharmaceutical Industries
PK-Merz - Merz, Adroka, Assos Ilac, Distribution Solutions Philippines, Dr. Kolassa & Merz, Germax, Grunenthal, Han Wha Pharma, Invida, Jacobson Medical, Kemofarmacija, Megapharm, Merck, NaturProdukt CZ, Oktal Pharma, Pharmacare, Summit, Weston Pharmaceutical, Zuellig Pharma
Prayanol - Instituto Sanitas
Symmetrel - Novartis, Alliance Pharmaceuticals, Aspen, Auden McKenzie, Bristol-Myers Squibb, Central Procurement & Supplies Unit, Chanelle Medical, Ciba-Geigy, Dr. Fisher Farma, DuPont, Endo Pharmaceuticals, Euro Registratie, Geigy Pharmaceuticals, Kemofarmacija, Medcor Pharmaceuticals, Middle East Pharmaceutical & Industrial Co., Mitra Healthcare, Pliva, R.P. Scherer, Sigma-Tau Pharmaceuticals, Sun Pharmaceutical Industries, Zuellig Pharma
Viregyt-K - Egis, Celltech
Zintergia - Novamed
Other medicines used in combinations with amantadine:
Acetaminophen
Aspirin
Astemizole
Caffeine
Chlorpheniramine
Metamizole
Phenylephrine
Phenylpropanolamine
Pseudoephedrine
References and external sources:
Amantadine main article on Wikipedia: https://en.wikipedia.org/wiki/Amantadine
Amantadine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Amantadine
Amantadine Hydrochloride on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Amantadine-Hydrochloride
Amantadine medicine on DrugBank: https://go.drugbank.com/drugs/DB00915
Amantadine FAQ on MedlinePlus (revised 11/15/2024): https://medlineplus.gov/druginfo/meds/a682064.html
Strides Pharma Amantadine Hydrochloride capsules drug label on DailyMed (revised April 16, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Chartwell Rx Amantadine Hydrochloride capsules drug label on DailyMed (revised October 10, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Symmetrel (Amantadine Hydrochloride) tablets and syrup official prescribing information from the U.S. FDA (revised January, 2009): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Symmetrel (Amantadine Hydrochloride) 100 mg capsules prescribing information from Novartis pharmaceutical company (revised April 2019): https://www.novartis.com/sg-en/sites/...
Gocovri (Amantadine) extended release capsules official website powered by Supernus Pharmaceuticals: https://www.gocovri.com/
PMS-Amantadine Hydrochloride capsules 100 mg and syrup 10 mg/ml product monograph from The Drug and Health Product Register (revised November 18, 2019): https://pdf.hres.ca/dpd_pm/00053945.PDF
Symmetrel (Amantadine Hydrochloride) capsules 100 mg consumer medicine information from NPS MedicineWise (revised March 2024): https://www.nps.org.au/assets/medicines/...
Alliance Pharmaceuticals Amantadine Hydrochloride 100 mg capsules package information leaflet for users on Medicines.org.uk (revised December 2024): https://www.medicines.org.uk/emc/files/pil.12143.pdf
Revised: March 2025
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