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Product Name: Fluoxetine
Generic Name: Fluoxetine Common Brands: Prozac, Prozac Weekly, Sarafem Pharmaceutical Categories: Antidepressants, Anti Anxiety Here is a list of pharma shops where you can buy Fluoxetine online, order cheap and qualitative Fluoxetine, purchase brand or generic Fluoxetine, compare pharmacy drug prices and cost of medications from popular and trusted online pharmacies and drugstores selling this or related pharmaceutical products:
Here is an additional general information about this medication active ingredient fluoxetine: Pharmacological action Fluoxetine is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Fluoxetine is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants fluoxetine apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Fluoxetine does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems. Pharmacokinetics Fluoxetine absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Fluoxetine easily penetrates through the BBB. Fluoxetine metabolized in the liver by demethylation to form the main active metabolite norfluoxetine. T1/2 of fluoxetine is 2-3 days, norfluoxetine - 7-9 days. Why is Fluoxetine prescribed? Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis. Dosage and administration The initial dose of Fluoxetine is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day. The maximum oral daily dose for adults is 80 mg. Fluoxetine side effects CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances. Digestive system: diarrhea, nausea. Metabolism: increased sweating, hypoglycemia, hyponatremia (especially in elderly patients and when hypovolemia). Reproductive system: decreased libido. Allergic reactions: skin rash, itching. Other: pain in joints and muscles, shortness of breath, increased body temperature. Fluoxetine contraindications Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to fluoxetine. Using during pregnancy and breastfeeding Fluoxetine is contraindicated during pregnancy and lactation. Special instructions Fluoxetine should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases. Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with fluoxetine increases the risk of epileptic seizures. With the simultaneous application of Fluoxetine and electroconvulsive therapy may develop prolonged seizures. Fluoxetine can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of fluoxetine before therapy MAO inhibitors should not be less than 5 weeks. Elderly patients need correction of dosing regimen. Safety of fluoxetine in children has not been established. During the period of treatment it needed to avoid use alcohol. During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions. Fluoxetine drug interactions Simultaneous administration of Fluoxetine with: Fluoxetine in case of emergency / overdose Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of fluoxetine (in combination with maprotiline, codeine, temazepam). Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective. |
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