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Product Name: Progesterone

Generic Name: Progesterone

Common Brands: Gesterol, Prometrium

Pharmaceutical Categories: Women's Health

Here is a list of pharma shops where you can buy Progesterone online, order cheap and qualitative Progesterone, purchase brand or generic Progesterone, compare pharmacy drug prices and cost of medications from popular and trusted online pharmacies and drugstores selling this or related pharmaceutical products:


Online Pharmacy Product
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  • Prometrium capsules 100 mg
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  • DRUGS FOR HEALTH
  • Prometrium capsules 100 mg
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  • GENERIC DOCTOR
  • Prometrium capsules 200 mg
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  • GENERIC DRUGS SHOP
  • Prometrium capsules 100 mg
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  • MEDICINES STORE
  • Prometrium capsules 100 mg
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  • Prometrium capsules 100 mg
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  • Here is an additional general information about this medication active ingredient progesterone:

    Pharmacological action

    Progesterone is a progestogen. This medication causes a transition in the endometrium of proliferative phase, called follicular hormone in the secretory phase, and after fertilization promotes its transition to a state necessary for the development of a fertilized egg. Progesterone reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the breast. It has no androgenic activity. This drug has little effect on protein metabolism, promotes fat deposit and accumulation of glucose in the liver and reduces the reabsorption of sodium in renal tubules.
    Progesterone has a blocking effect on the secretion of hypothalamic factors LH and FSH release, inhibits the formation of the pituitary gonadotropin-releasing hormone and inhibits ovulation.

    Pharmacokinetics

    After IM injection Progesterone is absorbed rapidly and almost completely. This medication metabolized in the liver, the majority of metabolites formed conjugates with glucuronic and sulfuric acids. T1/2 from plasma is a few minutes. This medicine is excreted in the urine - 50-60%, in feces - more than 10%. The number of metabolites which are excreted in the urine varies, depending on the phase of the corpus luteum.

    Why is Progesterone prescribed?

    Capsules Oral - premenstrual syndrome, fibrocystic breast disease, premenopausal, menopause, including premature, postmenopausal women - as the progestogen component of hormone replacement therapy (HRT) in combination with estrogen; Capsules Vaginal - HRT when dormant in the absence of ovarian progesterone (egg donation), support the luteal phase in preparation for in vitro fertilization, support the luteal phase in spontaneous or induced menstrual cycle, prevention of habitual abortion by threatening and progestogen deficiency, endocrine infertility, prevention of uterine fibroids, endometriosis.
    Solution in oil: amenorrhea, oligomenorrhea, algomenorrhea (on the basis of hypogenitalism), anovulatory metrorrhagia, infertility, endocrine (including failure of the corpus luteum), the threat of termination of pregnancy, diagnosis of estrogen.
    Gel for external use: mammalgia, disease of the breast.
    Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, recurrent miscarriage.
    Contraception.

    Dosage and administration

    Orally, intravaginally, IM, locally. The dosing regimen is individual. The dose, frequency and duration of treatment with Progesterone are determined according to the scheme depending on the indications and the clinical situation.

    Progesterone side effects, adverse reactions

    Cardiovascular system: increased blood pressure.
    Metabolic: edema.
    Digestive system: liver problems, jaundice, rarely (with prolonged use) - nausea, vomiting.
    Endocrine: rare (with prolonged use) - decreased libido, weight gain, pain and tension in the breasts, irregular uterine bleeding.
    CNS: rare (with prolonged use) - headache, depression.

    Progesterone contraindications

    Severe liver or kidney problems, hepatitis, thromboembolic disease, vaginal bleeding of not established genesis, breast carcinoma (except for cases in which progesterone is used in a combination therapy of this disease).

    Using during pregnancy and breastfeeding

    In cases of extreme necessity Progesterone may be used during pregnancy in the established failure of the corpus luteum hormone.
    Progesterone is not used in women planning a pregnancy in the near future.

    Special instructions

    Progesterone is used with caution in patients with cardiovascular disease, impaired liver or kidney problems, diabetes, asthma, epilepsy, migraine, depression.

    Progesterone drug interactions

    Progesterone reduces the intensity of the drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropin-releasing hormone of the anterior pituitary.
    This medication reduces the lactogenic effect of oxytocin.
    Progesterone enhances the action of diuretics, antihypertensive drugs, immunosuppressive drugs. Simultaneous administration of Progesterone with barbiturates it is marked decrease of progesterone effects.

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