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Product Name: Disulfiram
Generic Name: Disulfiram
Common Brands: Antabuse
Pharmaceutical Categories: Alcoholism
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Disulfiram (trade names include Antabuse, Antabus, Antaethyl, Anticol, Antietanol, Esperal, Etabus, Etiltox, Sarcoton, Tetradin, Teturam) is an alcohol-abuse deterrent medication from drugs used in alcohol dependence pharmacological group. This medicine is used for the treatment of alcoholism, chronic alcoholism, alcohol use disorder. It helps patients with alcohol abuse problems not to drink alcohol. Disulfiram is in research studies for the therapy of HIV, COVID-19, liver metastasis, metastatic melanoma, glioblastoma, non-small cell lung cancer, prostate cancer, parasitic infections such as amebiasis, diarrhea, liver abscess caused by Entamoeba histolytica and other deadly parasites. Antabuse works by interfering with the way the body metabolises alcohol (when taken with alcohol, this medication produces unpleasant effects).
Customers also buy these medications from the same pharmacological classes:
Acamprosate (Campral)
Buprenorphine (Temgesic)
Buprenorphine, Naloxone (Suboxone)
Calcium Carbimide (Abstem)
Carbamazepine (Tegretol)
Colchicine (Colcrys)
Diamorphine (Diamorf)
Gabapentin (Neurontin)
Levacetylmethadol (OrLAAM)
Levomethadone (Levothyl)
Lofexidine (BritLofex)
Methadone (Physeptone)
Nalmefene (Revex)
Naloxone (Narcan)
Naltrexone (Revia)
Nicotine (Nicotex, Nicotinell)
Oxcarbazepine (Trileptal)
Piracetam (Nootropil)
Prednisolone (Millipred)
Pregabalin (Lyrica)
Varenicline (Champix, Chantix)
Pharmaceutical and medical classifications:
Alcohol abuse deterrents
Anti alcoholism medications
Anti cancer drugs
Anti COVID pills
Antidotes
Antiparasitic medicines
Detoxifying agents
Drugs used in substance dependence
HIV treatment drugs
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N07 - Other nervous system drugs
N07B - Drugs used in addictive disorders
N07BB - Drugs used in alcohol dependence
N07BB01 - Disulfiram
P - Antiparasitic products, insecticides and repellents
P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents
P03A - Ectoparasiticides, incl. scabicides
P03AA - Sulfur containing products
P03AA04 - Disulfiram
Medical conditions for disulfiram in the International Statistical Classification of Diseases and Related Health Problems:
Amebiasis - A06
Acute amebic dysentery - A06.0
Human immunodeficiency virus [HIV] disease - B20
Malignant neoplasm of liver and intrahepatic bile ducts - C22
Malignant neoplasm of bronchus and lung - C34
Malignant neoplasm of unspecified part of unspecified bronchus or lung - C34.90
Malignant melanoma of skin - C43
Malignant neoplasm of prostate - C61
Malignant neoplasm of brain - C71
Malignant neoplasm of frontal lobe - C71.1
Secondary malignant neoplasm of respiratory and digestive organs - C78
Secondary malignant neoplasm of other and unspecified sites - C79
Alcohol related disorders - F10
Alcohol abuse - F10.1
Alcohol dependence - F10.2
Emergency use - U07
COVID-19 - U07.1
Pregnancy category:
B2 - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Disulfiram Base
Chemical, international, and other names of this drug:
Antiaethan
Bis(diethylthiocarbamyl) disulfide
Bis(N,N-diethylthiocarbamoyl)disulphide
Dissulfiram
Disulfiraami
Disulfirame
Disulfiramo
Disulfiramum
Disulfuram
Disulphuram
Diszulfiram
Ethyl Thiram
Ethyl Thiudad
Ethyl Thiurad
Ethyl Tuads
Ethyl Tuex
Ethyldithiourame
Ethyldithiurame
Ethyldithiourame
Etyl Tuex
Exhorran
N,N,N',N'-Tetraethylthiuram Disulphide
TETD
Tetraethylthioperoxydicarbonic Diamide
Tetraethylthiram Disulfide
Tetraethylthiram Disulphide
Tetraethylthiuram
Tetraethylthiuram Disulfide
Tetraethyl-Thiuram Disulfide
Tetraethylthiuram Disulphide
Tetraethylthiuram Sulfide
Tetraethylthiuramdisulfid
Tetraethylthiuran Disulfide
Tetraethylthiurium Disulfide
Tetraetilltiuramdisulfid
Thioperoxydicarbonic Diamide, Tetraethyl-
Thiuram Disulfide, Tetraethyl-
Thiuramdisulfide
Most known trade names (brands and generics) worldwide:
Alcobuse - T.O. Chemicals
Antabus - Wyeth, Actavis, Alpharma, Bohm, Chemomedica Medizintechnik und Arzneimittel, Farmo Quimica del Pacifico, HG Laboratorios, Inpac Pharma, Kemofarmacija, Kemwell Biopharma, Nobel Ilac, Team Medica
Antabuse - Wyeth, Actavis, Akacia Healthcare, Alpharma, Arrow Pharma, Aspen, Ayerst Laboratories, Barr Laboratories, CSL, Delfi Singapore, Dexxon, Duramed Pharmaceuticals, Neopharm, Odyssey Pharmaceuticals, Orphan Pharmaceutical, P & D Pharmaceuticals, Pharmacare, Sanofi, Sirton Pharmaceuticals, Stada, Teva
Antabuse Dispergettes - Wyeth
Antaethyl - Sanofi
Antalcol - Sintofarm
Anticol - Polfa Warszawa
Antietanol - Sanofi
Antikol - Polfa Warszawa
Antinol - Charoen Bhaesaj Lab, S. Charoen Bhaesaj Trading
Chronol - Kolson's India, Charoon Bhesaj
De-Quit - Gentech Healthcare
DFM - Psyco Remedies
Disulfiram - Intas Pharmaceuticals, Mylan, Par Pharmaceutical, Watson Pharmaceuticals
Esperal - Sanofi, Nycomed, Sofarimex Industria Quimica and Farmaceutica, Torrent Pharmaceuticals
Etabus - Ferring
Etiltox - AFOM Medical
Refusal - Artu Biologicals Europe
Sarcoton - Medley Industria Farmaceutica
Tetradin - Caldeira & Metelo
Teturam - Pharmstandard-Leksredstva, Tatchempharmpreparaty
Other medicines used in combinations with disulfiram:
Adenine
Benzyl Benzoate
Vitamin B3 (Nicotinamide)
Vorinostat
References and external sources:
Disulfiram main article on Wikipedia: https://en.wikipedia.org/wiki/Disulfiram
Disulfiram compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Disulfiram
Disulfiram medicine on DrugBank: https://go.drugbank.com/drugs/DB00822
Disulfiram FAQ on MedlinePlus (revised 08/15/2017): https://medlineplus.gov/druginfo/meds/a682602.html
Alcohol use disorder treatment (AUD, alcohol abuse treatment, alcoholism treatment) on MedlinePlus (revised September 26, 2017): https://medlineplus.gov/alcoholusedisorderaudtreatment.html
Antabuse (Disulfiram) tablets drug label on DailyMed (revised April 18, 2012): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Alvogen Disulfiram tablets drug label on DailyMed (revised January 30, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Antabuse (Disulfiram) 250 mg, 500 mg tablets for oral use product information from Medscape: https://reference.medscape.com/drug/disulfiram-343199
Antabuse (Disulfiram) 200 mg effervescent tablets product information from The Therapeutic Goods Administration (revised 16 June 2022): https://www.ebs.tga.gov.au/ebs/picmi/picmirepository...
Antabuse (Disulfiram) tablets consumer medicine information from NPS MedicineWise (revised January 2020): https://www.nps.org.au/assets/medicines/...
Disulfiram drug summary from PDR: https://www.pdr.net/drug-summary/Antabuse-disulfiram-681
Disulfiram 200 mg tablets package information leaflet on Medicines.org.uk (revised 06/2021): https://www.medicines.org.uk/emc/files/pil.11168.pdf
Revised: June 2022
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