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Product Name: Pramipexole
Generic Name: Pramipexole
Common Brands: Mirapex, Mirapexin, Pramirol
Pharmaceutical Categories: Alzheimer's disease, Parkinson's disease
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Pramipexole (trade names include Mirapex, Biopsol, Glepark, Intaxel, Mirapex-ER, Mirapexin, Pexola, Pexopram, Pramipex, Pramirol, Prexol, Sifrol) is an antiparkinson drug from dopamine agonists pharmacological group. This medication is indicated for the therapy of Parkinson's disease, restless legs syndrome (RLS). It is also off-label used to treat depression, rapid eye movement sleep behavior disorder, periodic limb movement disorder, tardive dyskinesia. Pramipexole is in research studies for the treatment of cerebral ischemia-related reperfusion injury (in combination with levodopa), traumatic brain injury, fibromyalgia, bipolar disorder, clinical depression, essential tremor, primary orthostatic tremor (shaky leg syndrome), sexual dysfunction, persistent genital arousal disorder.
Low levels of dopamine in human brain are associated with Parkinson's disease. This medicne works as dopamine-receptors agonist, and has the same effects as natural dopamine.
Related medications:
Amantadine (Symmetrel)
Amitriptyline (Elavil)
Apomorphine (Kynmobi)
Bromocriptine (Parlodel)
Cabergoline (Dostinex)
Carbidopa, Entacapone, Levodopa (Stalevo)
Carbidopa, Levodopa (Sinemet)
Dihydroergocryptine (Almirid)
Clonazepam (Klonopin, Rivotril)
Clonidine (Catapres)
Clozapine (Clozaril)
Diazepam (Valium)
Domperidone (Motilium)
Donepezil (Aricept)
Gabapentin (Neurontin)
Galantamine (Reminyl)
Lamotrigine (Lamictal)
Mirtazapine (Remeron)
Memantine (Namenda)
Modafinil (Provigil)
Pergolide (Permax, Prascend)
Piribedil (Trivastal)
Procyclidine (Kemadrin)
Quetiapine (Seroquel)
Rivastigmine (Exelon)
Ropinirole (Requip)
Rotigotine (Neupro)
Selegiline (Eldepryl)
Tramadol (Ultram)
Trihexyphenidyl (Artane)
Pharmaceutical and medical classifications:
Antidepressants
Antiparkinson agents
Antiparkinsonian drugs
Central nervous system agents
Dopamine receptor agonists
Dopaminergic antiparkinsonism agents
Dopaminergic medications
Medicines for the treatment of restless legs syndrome
Non ergot derivative dopamine receptor agonists
Sleep aid tablets
Urologicals
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
N - Nervous system
N04 - Anti-parkinson drugs
N04B - Dopaminergic agents
N04BC - Dopamine agonists
N04BC05 - Pramipexole
Medical conditions for pramipexole in the International Statistical Classification of Diseases and Related Health Problems (ICD):
Other psychoactive substance related disorders - F19
Other psychoactive substance use, unspecified - F19.9
Other psychoactive substance use, unspecified with other psychoactive substance-induced disorders - F19.98
Other psychoactive substance use, unspecified with psychoactive substance-induced sexual dysfunction - F19.981
Bipolar disorder - F31
Depressive episode - F32
Sexual dysfunction not due to a substance or known physiological condition - F52
Sexual arousal disorders - F52.2
Parkinson's disease - G20
Dystonia - G24
Drug induced dystonia - G24.0
Drug induced subacute dyskinesia - G24.01
Other extrapyramidal and movement disorders - G25
Essential tremor - G25.0
Other specified forms of tremor - G25.2
Other specified extrapyramidal and movement disorders - G25.8
Restless legs syndrome - G25.81
Sleep disorders - G47
Parasomnia - G47.5
REM sleep behavior disorder - G47.52
Sleep related movement disorders - G47.6
Periodic limb movement disorder - G47.61
Other cerebrovascular diseases - I67
Other specified cerebrovascular diseases - I67.8
Cerebral ischemia - I67.82
Other and unspecified soft tissue disorders, not elsewhere classified - M79
Fibromyalgia - M79.7
Sexual dysfunction, unspecified - R37
Intracranial injury - S06
Diffuse traumatic brain injury - S06.2
Pregnancy category:
B3 - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Pramipexole Base
Pramipexole Dihydrochloride
Pramipexole Dihydrochloride Monohydrate
Pramipexole Hydrochloride
Chemical, international, and other names of this drug:
(-)-Pramipexole
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)-
Furfuryl Acetate
Pramipeksol
Pramipexol
Pramipexol Diclorhidrato
Pramipexol Diclorhidrato Monohidrato
Pramipexole DiHCl
Pramipexole DiHCl Monohydrate
Pramipexole HCl
Pramipexolo
Pramipexolum
Most known trade names (brands and generics) worldwide:
Apo-Pramipexole - Apotex, Arrotex Pharmaceuticals, Southern Cross Pharma
Biopsol - Drugtech Laboratorio, Recalcine Laboratorios
Glepark - Glenmark Pharmaceuticals, Bennett, EQL Pharma
Intaxel - Chile Laboratorios
Minergi - Supera Rx
Mirapex - Boehringer Ingelheim, Pfizer
Mirapex-ER - Boehringer Ingelheim
Mirapexin - Boehringer Ingelheim, Pfizer
Mirator - Torrent Pharmaceuticals
Oprymea - KRKA, Consilient Health
Parmital - Tecnofarma
Parpex - Zydus Cadila
Pexola - Boehringer Ingelheim
Pexopram - La Renon Healthcare
Pramipex - Sun Pharmaceutical Industries
Pramipexol - Actavis, Cinfa Laboratorios, Mylan, Ranbaxy, Ratiopharm, Sandoz, Stada, Teva
Pramipexole - Actavis, Apotex, Mylan, Pro Doc, Sandoz, Teva, Watson Pharmaceuticals
Pramirol - Intas Pharmaceuticals
Pramirol SR - Intas Pharmaceuticals
Prexol - Alteus Biogenics
Ramipex - Devatis, Torrent Pharmaceuticals
Sifrol - Boehringer Ingelheim
Sifrol ER - Boehringer Ingelheim
Other medicines used in combinations with pramipexole:
Carbidopa
Levodopa
References and external sources:
Pramipexole main article on Wikipedia: https://en.wikipedia.org/wiki/Pramipexole
Pramipexole compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Pramipexole
Pramipexole Dihydrochloride on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Pramipexole-Dihydrochloride
Pramipexole medicine on DrugBank: https://go.drugbank.com/drugs/DB00413
Pramipexole FAQ on MedlinePlus (revised 02/15/2022): https://medlineplus.gov/druginfo/meds/a697029.html
Mirapex (Pramipexole Dihydrochloride) tablets drug label on DailyMed (revised December 29, 2010): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
American Health Packaging Pramipexole Dihydrochloride tablets drug label on DailyMed (revised October 2, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Mirapex (Pramipexole Dihydrochloride) tablets for oral use official prescribing and patient information from the U.S. FDA (revised 07/2021): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Mirapex ER (Pramipexole Dihydrochloride) extended-release tablets official prescribing and patient information from the U.S. FDA (revised 07/2021): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Mirapex (Pramipexole Dihydrochloride) 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, 1.5 mg tablets prescribing and patient information from Boehringer Ingelheim pharmaceutical company (revised 07/2021): https://pro.boehringer-ingelheim.com/us/sites/default/files/Mirapex.pdf
Mirapex (Pramipexole Dihydrochloride Monohydrate) 0.125 mg, 0.25 mg tablets product monograph and patient information from Boehringer Ingelheim (revised March 20, 2024): https://www.boehringer-ingelheim.com/ca/pdf/mirapexpmenpdf
Apo-Pramipexole 0.125 mg, 0.25 mg, 1 mg tablets consumer medicine information from NPS MedicineWise (revised January 2024): https://www.nps.org.au/assets/medicines/...
Mirapexin (Pramipexole) 0.088 mg, 0.18 mg, 0.35 mg, 0.7 mg tablets package information leaflet for users on Medicines.org.uk (revised 04/2024): https://www.medicines.org.uk/emc/files/pil.1553.pdf
Revised: March 2025
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