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Product Name: Clonidine
Generic Name: Clonidine
Common Brands: Catapres, Catapresan, Duraclon
Pharmaceutical Categories: Cardio, Blood Pressure, Cholesterol
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Clonidine (trade names include Catapres, Arkamin, Atensina, Catapresan, Catapres-TTS, Clonidin Ratiopharm, Teva-Clonidine, Clonistada, Dixarit, Isoglaucon, Kapvay, Nexiclon-XR, Normopresan, Novo-Clonidine) is an antihypertensive, antimigraine, ophthalmological drug from sympathomimetics, antimigraine preparations, and imidazoline receptor agonists pharmacological groups. This medicine is used for the treatment of hypertension (high blood pressure), resistant hypertension, hypertensive emergency alone or with diuretics and other antihypertensive drugs. It works by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.
Clonidine HCl in ophthalmic/eye drops pharmaceutical form is prescribed as sympathomimetic in glaucoma therapy.
This medication is also indicated for migraine prevention, to treat migraines with or without aura, migraine headaches, spasticity, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, tic disorders, impulse control disorder, restless legs syndrome (RLS), clozapine-induced sialorrhea, menopausal flushing (hot flashes associated with menopause), vasomotor symptoms associated with menopause, perimenopausal symptoms, dysmenorrhea (menstrual cramps, pain during menstruation), facial flushing and redness associated with rosacea, postherpetic neuralgia, postanesthetic shivering, severe pain, certain pain conditions, atrial fibrillation, postural orthostatic tachycardia syndrome, tardive dyskinesia, hyperhidrosis, ulcerative colitis; diarrhea associated with diabetes, irritable bowel syndrome (IBS), fecal incontinence, intestinal failure, withdrawal-associated diarrhea, neuroendocrine tumors and cholera; for diagnosis of pheochromocytoma (clonidine suppression test); to prevent oral mucositis in head and neck cancer patients undergoing radiation therapy.
Catapres helps to relieve withdrawal symptoms from alcohol (ethanol dependence), benzodiazepines, dexmedetomidine, narcotics, heroin, opioids, nicotine (smoking cessation).
Other off-label uses of clonidine are include psychiatric disorders, stress, insomnia, sleep disorders, hyperarousal (hypervigilance), post-traumatic stress disorder (PTSD), borderline personality disorder, bipolar disorder, other anxiety disorders; as mild sedative drug; as premedication before surgery or procedures; to manage symptoms of hallucinogen persisting perception disorder.
Its topical and epidural forms (transdermal patches, plasters, TTS) are used and studied for pain relief during heart attack, postoperative and intractable pain, to treat diabetic neuropathy.
Customers also buy these medications from the same pharmacological classes:
Amlodipine (Norvasc)
Atenolol (Tenormin)
Baclofen (Lioresal)
Bisoprolol (Zebeta)
Diltiazem (Cartia)
Divalproex (Depakote)
Doxazosin (Cardura)
Enalapril (Vasotec)
Guanfacine (Estulic)
Hydrochlorothiazide (Microzide)
Iprazochrome (Divascan)
Irbesartan (Avapro)
Lisinopril (Zestril)
Mebeverine (Colospa)
Methocarbamol (Robaxin)
Metoprolol (Lopressor, Toprol-XL)
Moxonidine (Physiotens)
Nifedipine (Adalat)
Olmesartan (Benicar)
Oxetorone (Nocertone)
Pizotifen (Sandomigran)
Propranolol (Inderal)
Pyridostigmine (Mestinon)
Ramipril (Altace)
Rilmenidine (Hyperium)
Rizatriptan (Maxalt)
Ropinirole (Requip)
Sotalol (Betapace)
Sumatriptan (Imitrex)
Tizanidine (Zanaflex)
Tolonidine (Euctan)
Topiramate (Topamax)
Valsartan (Diovan)
Verapamil (Calan)
Pharmaceutical and medical classifications:
Alcohol dependence treatment
Anti stress pills
Antiglaucoma medications
Antihypertensive drugs
Antimigraine tablets
Antisympathotonic agents
Anxiolytics
Centrally acting alpha-2 adrenergic agonists
Drug rehab
Drugs to treat withdrawal symptoms
Narcotic dependence treatment
Opioid dependence treatment
Ophthalmological preparations
Pain relief medicines
Postoperative care
Premedication drugs
Sedatives
Skin care products
Smoking cessation
Women's health
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
C - Cardiovascular system
C02 - Antihypertensives
C02A - Antiadrenergic agents, centrally acting
C02AC - Imidazoline receptor agonists
C02AC01 - Clonidine
N - Nervous system
N02 - Analgesics
N02C - Antimigraine preparations
N02CX - Other antimigraine preparations
N02CX02 - Clonidine
S - Sensory organs
S01 - Ophthalmologicals
S01E - Antiglaucoma preparations and miotics
S01EA - Sympathomimetics in glaucoma therapy
S01EA04 - Clonidine
Medical conditions for clonidine in the International Statistical Classification of Diseases and Related Health Problems:
Cholera - A00
Zoster [herpes zoster] - B02
Other postherpetic nervous system involvement - B02.29
Malignant neuroendocrine tumors - C7A
Malignant neoplasm of medulla of unspecified adrenal gland - C74.10
Benign neoplasm of other and unspecified endocrine glands - D35
Diabetes mellitus - E08-E13
Type 2 diabetes mellitus - E11
Type 2 diabetes mellitus with diabetic neuropathy, unspecified - E11.40
Alcohol related disorders - F10
Opioid related disorders - F11
Sedative, hypnotic, or anxiolytic related disorders - F13
Hallucinogen related disorders - F16
Hallucinogen use, unspecified with hallucinogen persisting perception disorder (flashbacks) - F16.983
Nicotine dependence - F17
Other psychoactive substance related disorders - F19
Bipolar disorder - F31
Reaction to severe stress, and adjustment disorders - F43
Post-traumatic stress disorder (PTSD) - F43.1
Specific personality disorders - F60
Borderline personality disorder - F60.3
Impulse disorders - F63
Attention-deficit hyperactivity disorders - F90
Tic disorder - F95
Tourette's disorder - F95.2
Dystonia - G24
Drug induced subacute dyskinesia - G24.01
Other extrapyramidal and movement disorders - G25
Restless legs syndrome - G25.81
Sleep disorders - G47
Insomnia - G47.0
Hemiplegia and hemiparesis - G81
Pain, not elsewhere classified - G89
Other acute postprocedural pain - G89.18
Chronic pain syndrome - G89.4
Disorders of autonomic nervous system - G90
Postural orthostatic tachycardia syndrome [POTS] - G90.A
Glaucoma - H40
Essential (primary) hypertension - I10
Secondary hypertension - I15
Hypertensive crisis - I16
Hypertensive urgency - I16.0
Acute myocardial infarction - I21
Atrial fibrillation and flutter - I48
Other cardiac arrhythmias - I49
Other specified cardiac arrhythmias - I49.8
Migraine - G43
Diseases of salivary glands - K11
Disturbances of salivary secretion - K11.7
Stomatitis and related lesions - K12
Oral mucositis (ulcerative) - K12.3
Ulcerative colitis - K51
Irritable bowel syndrome - K58
Other functional intestinal disorders - K59
Intestinal malabsorption - K90
Rosacea - L71
Pain and other conditions associated with female genital organs and menstrual cycle - N94
Primary dysmenorrhea - N94.4
Secondary dysmenorrhea - N94.5
Menopausal and other perimenopausal disorders - N95
Menopausal and female climacteric states - N95.1
Fecal incontinence - R15
Other symptoms and signs involving the digestive system and abdomen - R19
Other skin changes - R23
Flushing - R23.2
Fever of other and unknown origin - R50
Postprocedural fever - R50.82
Pain, unspecified - R52
Generalized hyperhidrosis - R61
Encounter for other special examination without complaint, suspected or reported diagnosis - Z01
Encounter for procedures for purposes other than remedying health state - Z41
Problems related to life management difficulty - Z73
Stress, not elsewhere classified - Z73.3
Pregnancy category:
B3 - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Clonidine Base
Clonidine Hydrochloride
Clonidine Tosylate
Chemical, international, and other names of this drug:
1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-
2,6-Dichloro-N-2-imidazolidinylidenebenzenamide
Chlornidinum
Clonidin
Clonidina
Clonidine HCl
Clonidinehydrochloride
Clonidinhydrochlorid
Clonidini Hydrochloridum
Clonidinum
Clorhidrato de Clonidina
Hidrocloruro de Clonidina
Klonidiin
Klonidiini
Klonidin
Klonidine
Klonidinhydroklorid
Klonidino
Klonidyna
Most known trade names (brands and generics) worldwide:
Alphapres - Metrolink Pharma Phils, Metro Drug Distribution
Apo-Clonidine - Apotex, Hind Wing
Arkamin - Unichem Laboratories
Atensina - Boehringer Ingelheim
Catapres - Boehringer Ingelheim
Catapresan - Boehringer Ingelheim, Delpharm, Euro Registratie, Fher Laboratorios, Unilfarma Uniao Internacional Laboratorios Farmaceuticos
Catapres-TTS - Boehringer Ingelheim
Clonidin - Ratiopharm
Clonidin Retard - Ratiopharm
Clonidina - Arena Group, Fulton Medicinali
Clonidine - Mylan, Pro Doc, Sandoz, Sanis Health, Teva
Clonistada - Stada
Clonnirit - Rafa Laboratories
Clophelin - Dalkhimpharm, Moskhimfarmpreparaty, Vifiteh
Dixarit - Boehringer Ingelheim, B & S Healthcare, Delpharm, Diethelm, Expono
Duraclon - AAI Pharmaceuticals, Bioniche Pharma, Xanodyne Pharmaceuticals
Isoglaucon - Alcon, Agepha
Jenloga - Shionogi, Patheon
Kapvay - Concordia Pharmaceuticals, Shionogi, CJ HealthCare
Nexiclon-XR - Tris Pharma
Normopresan - Rafa Laboratories
Novo-Clonidine - Novopharm
Paracefan - Boehringer Ingelheim
Other medicines used in combinations with clonidine:
Bencyclane Fumarate
Bendroflumethiazide
Chlorthalidone
Cyclothiazide
Hydrochlorothiazide
Proxodolol
Triamterene
References and external sources:
Clonidine main article on Wikipedia: https://en.wikipedia.org/wiki/Clonidine
Clonidine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Clonidine
Clonidine Hydrochloride on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Clonidine-hydrochloride
Clonidine medicine on DrugBank: https://go.drugbank.com/drugs/DB00575
Clonidine Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000538
Clonidine FAQ on MedlinePlus (revised 05/15/2017): https://medlineplus.gov/druginfo/meds/a682243.html
Clonidine Transdermal Patch FAQ on MedlinePlus (revised 09/15/2016): https://medlineplus.gov/druginfo/meds/a608049.html
Actavis Clonidine tablets drug label on DailyMed (revised June 4, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Hikma Clonidine injections drug label on DailyMed (revised June 27, 2022): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Catapres-TTS (Clonidine) patch drug label on DailyMed (revised April 20, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Catapres (Clonidine Hydrochloride) tablets 0.1, 0.2 and 0.3 mg official prescribing information from the U.S. FDA (revised October 2009): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Catapres-TTS (Clonidine) transdermal therapeutic system official prescribing information and patient instructions from the U.S. FDA (revised October 2011): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Kapvay (Clonidine Hydrochloride) 0.1 mg extended-release tablets for oral use official prescribing and patient information from the U.S. FDA (revised 02/2020): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Catapres (Clonidine Hydrochloride) tablets 0.1 mg, 0.2 mg, 0.3 mg prescribing information from Boehringer Ingelheim pharmaceutical company (revised August 2016): https://content.boehringer-ingelheim.com/DAM/...
Catapres 100 (Clonidine HCl) tablets consumer medicine information from The Therapeutic Goods Administration (revised January 2021): https://www.ebs.tga.gov.au/ebs/picmi/...
Catapres (Clonidine Hydrochloride) tablets 100 micrograms package information leaflet for users on the Health Products Regulatory Authority (revised December 2021): https://www.hpra.ie/img/uploaded/...
Revised: December 2022
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