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Product Name: Hydralazine
Generic Name: Hydralazine
Common Brands: Apresoline
Pharmaceutical Categories: Cardio, Blood Pressure, Cholesterol
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Hydralazine (trade names include Apresoline, Apresol, Apresolina, Aprezine, Hydrapres, Hydrastat, Hylazine) is an antihypertensive drug from hydrazinophthalazine derivatives pharmacological group. This medicine is used for the treatment and to control of hypertension, heart failure, high blood pressure in pregnancy, essential hypertension, hypertensive emergency, malignant hypertension, very high blood pressure resulting in symptoms. It has also been studied to treat myelodysplastic syndrome. Hydralazine works as a direct-acting smooth muscle relaxant by causing arterial vasodilation.
Related medications:
Amlodipine (Norvasc)
Candesartan (Atacand)
Carvedilol (Coreg)
Dihydralazine (Nepresol)
Doxazosin (Cardura)
Endralazine (Miretilan)
Hydralazine, Isosorbide Dinitrate (BiDil)
Hydrochlorothiazide (Microzide)
Irbesartan (Avapro)
Isosorbide Dinitrate (Isordil)
Labetalol (Trandate)
Losartan (Cozaar)
Methyldopa (Aldomet)
Metoprolol (Lopressor, Toprol-XL)
Nifedipine (Adalat)
Perindopril (Aceon)
Propranolol (Inderal)
Ramipril (Altace)
Telmisartan (Micardis)
Terazosin (Hytrin)
Valsartan (Diovan)
Verapamil (Calan)
Pharmaceutical and medical classifications:
Antihypertensive drugs
Cardiovascular medications
Direct-acting smooth muscle relaxants
Direct vasodilators
Hydrazines
Monoamine metabolism modulators
Nonsympatholytic vasodilatory antihypertensives
Peripheral vasodilators
The Anatomical Therapeutic Chemical (ATC) classification system (developed by the World Health Organization):
C - Cardiovascular system
C02 - Antihypertensives
C02D - Arteriolar smooth muscle, agents acting on
C02DB - Hydrazinophthalazine derivatives
C02DB02 - Hydralazine
Medical conditions for hydralazine in the International Statistical Classification of Diseases and Related Health Problems (ICD):
Myelodysplastic syndromes - D46
Essential (primary) hypertension - I10
Hypertensive crisis - I16
Hypertensive emergency - I16.1
Heart failure - I50
Systolic (congestive) heart failure - I50.2
Gestational [pregnancy-induced] hypertension without significant proteinuria - O13
Unspecified maternal hypertension - O16
Pregnancy category:
C - Australia
C - United States (Risk cannot be ruled out)
Forms of active pharmaceutical ingredients (APIs):
Hydralazine Base
Hydralazine Hydrochloride
Hydralazine Resinate
Hydralazine Sulphate
Chemical, international, and other names of this drug:
1(2H)-Phthalazinone hydrazone
1-Hydrazinophthalazine
1-Phthalazinylhydrazine
6-Hydralazine
Hidralazin
Hidralazina
Hydralatsiini
Hydralazin
Hydralazine HCl
Hydralazine Polistirex
Hydralazinehydrochloride
Hydralazinhydrochlorid
Hydralazini Hydrochloridum
Hydralazinum
Hydralazyna
Hydrallazine
Hydrazinophthalazine
Hydrazone 1(2H)-Phthalazinone
Idralazina
Phthalazine, 1-hydrazino-
Phthalazinone, Hydrazone
Most known trade names (brands and generics) worldwide:
Alphapress - Alphapharm, Unipharm
Apo-Hydralazine - Apotex
Apresol - Ordain Health Care
Apresolina - Novartis, Sandoz
Apresoline - Novartis, AFT Pharmaceuticals, Amdipharm Mercury International, Concordia International, Expono, Invida, Link Pharmaceuticals, Mason Pharmaceuticals, Medilink Pharmaceuticals, N.G., Rottendorf Pharma, Sovereign Medical, SteriMax, Waymade Healthcare, Zuellig Pharma
Aprezine - RMPL Pharma
Dralgeen - Bharat Serums & Vaccines
Hidralazina - Farmindustria, Kronos Laboratorios
Hydralaze - Dahlia Pharmaceutical
Hydralazine - Actavis, Eon Labs, Generics UK, Mylan, Pliva, Sandoz, Teva
Hydrapres - Rubio Laboratorios, Omedir Laboratorios, Spedrog Caillon
Hydrastat - Johnlee Pharmaceuticals
Hylazine - Healing Pharma
Hyperphen - Aspen
Unilazine - Cognitus Life Sciences
Other medicines used in combinations with hydralazine:
Atenolol
Bendroflumethiazide
Chlorthalidone
Hydrochlorothiazide
Isosorbide Dinitrate
Labetalol
Methyldopa
Metoprolol
Oxprenolol
Propranolol
Reserpine
References and external sources:
Hydralazine main article on Wikipedia: https://en.wikipedia.org/wiki/Hydralazine
Hydralazine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Hydralazine
Hydralazine Hydrochloride on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Hydralazine-Hydrochloride
Hydralazine medicine on DrugBank: https://go.drugbank.com/drugs/DB01275
Hydralazine FAQ on MedlinePlus (revised 06/15/2017): https://medlineplus.gov/druginfo/meds/a682246.html
Camber Pharmaceuticals Hydralazine Hydrochloride tablets drug label on DailyMed (revised January 9, 2025): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Glenmark Hydralazine Hydrochloride tablets drug label on DailyMed (revised May 24, 2024): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Apresoline (Hydralazine Hydrochloride) tablets official prescribing information from the U.S. FDA (revised 05/1995): https://www.accessdata.fda.gov/drugsatfda_docs/label...
American Regent Hydralazine Hydrochloride injections prescribing information from the U.S. FDA (revised 02/2013): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Apresoline (Hydralazine Hydrochloride) injections 20 mg / ml product monograph and patient medication information from The Drug and Health Product Register (revised 02/2013): https://pdf.hres.ca/dpd_pm/00067408.PDF
Amdipharm Hydralazine 25 mg tablets package information leaflet for patients from Medicines.org.uk (revised November 2023): https://www.medicines.org.uk/emc/files/pil.6707.pdf
Revised: March 2025
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